Clinical Study Of Modified Dingxian Decoction Combined With Sodium Valproate On The Treatment Of Epilepsy With Phlegm And Blood Stasis Blocking Collaterals After Ischemic Stroke And Its Effect On Hs-CRP

Background: To observe the clinical efficacy and safety of Modified Dingxian Decoction combined with Sodium Valproate on the treatment of phlegm and blood stasis obstruction type of epilepsy after ischemic stroke,and its effect on serum hs-CRP(hypersensitive C-creative protein).Methods:A randomized controlled clinical study was conducted to select 67 outpatients and inpatients with epilepsy after ischemic stroke who met the inclusion criteria from March 2018 to March 2019 in Encephalopathy Area 1,First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine.The patients were randomly divided into treatment group(33 cases)and control group(34 cases).The control group was treated with sodium valproate for anti-epilepsy,while the treatment group was treated with Modified Dingxian Decoction combined with Sodium Valproate for anti-epilepsy.Before and after treatment,seizure frequency,seizure time,TCM syndrome score,quality of life scale score of epilepsy patients,National Institutes of Health Stroke Scale,serum hs-CRP,EEG,safety index and adverse reactions were observed and recorded to evaluate the clinical efficacy and safety of the prescription.Results:After 2 months of treatment,the effective rate of seizure control on the treatment group was 93% better than that in the control group 83%(P < 0.05);the scores of TCM syndromes,quality of life scale of epilepsy patients and stroke scale of National Institutes of Health in the treatment group were better than those in the control group(P < 0.05);the decrease of hs-CRP in the treatment group was significantly higher than that in the control group(P < 0.05).The difference was significant(P > 0.05).Conclusions:Modified Dingxian Decoction combined with Sodium Valproate on the treatment of post-ischemic stroke epilepsy of phlegm and blood stasis obstruction collateral type has significant clinical efficacy,safe and reliable,can promote the recovery of nerve function,improve the quality of life of epilepsy patients,can reduce the level of hs-CRP in serum of post-ischemic stroke epilepsy.