STAT3 And ZEB1 Expression In Esophageal Squamous Cell Carcinoma And Their Relationship With Radiosensitivity

Objective: To study the expressions of signal transducer and activator of transcription 3(STAT3)and zine finger E-box-binding Protein(ZEB1)in esophageal squamous cell carcinoma(ESCC)and their relationship with radiosensitivity.Methods: The expressions of STAT3 and ZEB1 were observed using the immunohistochemical method in 100 cases of ESCC before radiotherapy,and their relationship with radiosensitivity was analyzed.Results: In 100 cases of esophageal carcinoma patients,the positive of STAT3 and ZEB1 were 66%(66/100)and 64%(64/100).Low differentiation and clinical stage of T3 and T4 STAT3 expression positive rate was 85.7%(30/35)?82.9%(42/51),which were significantly higher than medium and high differentiation and clinical stage of T1 + T2 of 55.4%(36/65)?49.0%(24/49),differences were statistically significant(P< 0.05).Low differentiation and clinical stage for T3 and T4 organization ZEB1 expression positive rate was 85.7%(30/35)?76.5%(39/51),were significantly higher than medium and high differentiation and clinical stage of T1 + T2 of 52.3%(34/65)?51.0%(25/49),the difference had statistical significance(P< 0.05).STAT3 and ZEB1 expression positive rate of effective radiation group were significantly lower than radiotherapy invalid group,differences were statistically significant(P< 0.05).STAT3 and ZEB1 were positively correlation with statistical significance(r=0.341,P=0.001).Conclusion: STAT3 and ZEB1 expressions were negatively correlated with the radiosensitivity of ECSS.STAT3 and ZEB1 may be used as molecular markers to predict the sensitivity of radiotherapy for patients with ESCC.