The Correlation Study Of Traditional Chinese Medicine Syndrome Differentiation Of Chronic Heart Failure And Ang(1-7)?NT-proBNP

Objective:Through testing the level of Angiotensin 1-7?Ang?1-7???B-typeamino-terminal natriuretic peptide?NT-proBNP?with chronic heart failure?CHF?,we explore the relevance among Ang?1-7?and NT-proBNP,different syndrome of traditional Chinese medicine?TCM?with CHF and the severity of heart failure,in order to provide some clinical evidence for the treatment of Integrative Medicine.Method:According to left ventricular ejection fraction?LVEF?,we selected 35 cases of Heart failure with preserved ejection fraction?HFpEF?patients,35 cases of Heart failure with midrange ejection fraction?HFmrEF?patients,and 35 cases of Heart failure with reduced ejection fraction?HFrEF?patients from the department of cardiology in the traditional Chinese and Western medicine of Shandong.We set up 35 health persons as a control group.We collected the patients'general information,including symptoms,signs,auxiliary examination,clinical data of tongue and pulse.According to TCM syndrome classification,they were divided into three groups:the Qi Yin deficiency group,the Qi deficiency and blood stasis group,the heart kidney yang deficiency group.The level of NT-pro BNP in the blood was measured by Triage quantitative detector,and the level of Ang?1-7?in the blood was measured by enzyme linked immunosorbent assay?ELISA?.We processed and analyzed these data through SPSS17.0 statistical software.Results:1.comparison of basic data between each groupCompared with the control group,the HFpEF group,HFmrEF group,HFrEF group gender,age,TC,TG,AST,ALT levels are no significant difference?P>0.05?,but Cr BUN HDL-C,LDL-C values are significantly higher than those in control group?P<0.05?.2.comparison of Ang?1-7?and NT-proBNP between each groupCompared with the control group,the HFrEF group,HFmrEF group,HFpEF group Ang?1-7?and NT-proBNP levels in the blood increase significantly?P<0.01?.Compared with the HFpEF group,the HFrEF group,HFmrEF group Ang?1-7?and NT-proBNP levels in the blood increase significantly?P<0.01?.Compared with the HFmrEF group,the HFrEF group Ang?1-7?and NT-proBNP levels in the blood increases significantly?P<0.01?.3.Ang?1-7?level is correlated with LVEF?r=-0.705,P=0.00?,and correlated with NT-pro BNP level?r=0.596,P=0.00?.4.Comparison of TCM syndrome type with Ang?1-7?,NT-pro BNP and LVEFCompared with the Qi Yin deficiency group,the levels of Ang?1-7?,NT-pro BNP and LVEF in the Qi deficiency and blood stasis group and the heart kidney yang deficiency group are significantly different?P<0.01?.Compared with the Qi deficiency and blood stasis group,the levels of Ang?1-7?,NT-pro BNP and LVEF in the heart kidney yang deficiency group are significantly different?P<0.01?.TCM syndrome types of CHF is correlated with LVEF?r=-0.812,P=0.00?,and correlated with NT-pro BNP?Ang?1-7??r₁=0.705,r₂=0.693,P=0.00?.5.The Qi and yin deficiency mainly distribute in the HFpEF group,Qi deficiency and blood stasis mainly distributes in HFmrEF group,heart kidney yang deficiency mainly distributes in HFrEF group.Conclusion:1.The Ang?1-7?and NT-pro BNP levels in the blood of CHF patients are higher than those of normal people.The Ang?1-7?and NT-pro BNP levels in the blood are negatively correlated with LVEF.The higher the degree of heart failure,the higher the levels of Ang?1-7?and NT-pro BNP.2.The changes of Ang?1-7?and NT-pro BNP levels in blood of CHF patients gradually increase with the conversion of qi yin deficiency syndrome,qi deficiency and blood stasis syndrome to heart yang deficiency syndrome.The LVEF level gradually decreases with the transformation of qi yin deficiency syndrome,qi deficiency and blood stasis syndrome to heart yang deficiency syndrome.3.Among the patients with mild heart failure,TCM syndromes are mostly qi yin deficiency syndrome.Among the patients with severe heart failure,TCM syndromes are mostly qi deficiency and blood stasis syndrome,heart yang deficiency syndrome.