| Objective:To retrospectively analyze the clinical data of 142 patients with interstitial lung disease in the past 5 years,and summarize the classification of diseases,the distribution of syndrome types and the rules of tumor markers,and provide data for the study of ILD.Methods: Retrospective Analysis of 142 patients hospitalized by the Chinese Medical Hospital affiliated to Xinjiang Medical University from 1982 to 1818 in the Department of Respiratory Diseases for interstitial lung disease,analysis of general information,TCM syndrome types,and serological tumor markers to identify elevated ILD patients.Results: 1.A total of 142 cases were collected,including 67 females,mean age: 65.98 ± 10.15 years old,male: 75 cases,mean age: 69.56 ± 10.25;95 people who smoked,47 people who did not smoke;2.The distribution ratio of TCM syndromes is as follows: 42 cases of evidence: 14 cases(10%)of dry evil and lung injury,12 cases(8%)of phlegm and blood stasis,11 cases(7%)of phlegm and blood stasis,There were 5 cases(3%)and 26 cases of deficiency syndrome: 21 cases(14%)with lung,spleen and kidney deficiency,6 cases(4%)with deficiency of lung and yin;74 cases with false and complicated syndromes: 74 cases(51%)with qi deficiency and blood stasis 3.This study included 142 cases,of which 68 were clearly diagnosed and 74 were not clearly classified.Among the patients with clear diagnosis,connective tissue was associated with 60 cases(42%),including 22 cases(15%)related to rheumatoid,16 cases(11%)related to Sjogren’s syndrome,and other connective tissues(not classified).11 cases(7.7%),ANCA-associated vasculitis in 8 cases(5.6%),anti-JO-1 antibody syndrome in 1 case(0.7%),systemic sclerosis in 1 case(0.7%),scleroderma-related 1 Case(0.7%);8 cases(5.6%)of idiopathic fibrosis;4.There were differences in CA50 and CA125 between men and women in this disease.The smoking and non-smoking patients were in CA50,CA199,There are differences in the three indicators of CA125;5.The proportion of tumor markers in the collected ILD patients is greater than the normal reference range: 92 cases(64%)in CEA,87 cases(61%)in CA125,and 81 cases in CA153.(57%),79 cases(55%)of Cyfra21-1,57 cases(40%)of NSE,43 cases(30%)of CA724,40 cases(28%)of CA199,and 7 cases of CA50(26%)),SCC a total of 37 cases(6%);6.CA125,CA724 have significant differences in different types of ILD patients: in the CA125 index,rheumatoid related>ANCA-related vasculitis related>Other knots Tissue-related(cannot be classified)> idiopathic fibrosis > Sjogren’s syndrome,the highest correlation was found in ANCA-associated vasculitis in CA724,and the difference was statistically significant.7.The abnormal tumor marker detection rate in different types of ILD patients was CA125.,SCC is statistically different: rheumatoid associated in CA125(81.0%)> ANCA-associated vasculitis(62.5%)> other connective tissue-related(cannot be classified)(54.5%)> idiopathic fibrosis(37.5%)> Sjogren’s syndrome yield(31.2%),rheumatoid related in SCC(38.1%)> ANCA-associated vasculitis(37.5%)> Sjogren’s syndrome(12.5%),other connective tissue-related(cannot There was no abnormality in the classification of idiopathic fibrosis;8.There was no significant difference in CEA,CA50,CA153,CA199,CA125,CA724,NSE,Cyfra21-1,SCC between different TCM syndromes(P< 0.05).Conclusion: 1.The proportion of connective tissue in ILD is the most,and it is mostly female;2.In this study,the distribution of TCM syndromes is the most common syndrome of deficiency and qi deficiency(qi deficiency and blood stasis),and ILD patients with different TCM syndromes There were no significant differences in tumor markers.3.CEA,CA125,CA153,and Cyfra21-1 were generally elevated in patients with ILD.The increase in CA125 and SCC was the most obvious in patients with rheumatoid associated with connective tissue ILD.CA724 in ANCA-associated vasculitis The middle rise is most obvious;4.Tumor markers have certain value in the diagnosis and classification of ILD patients. |
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