| Objective:To investigate the value of combined detection of serum alpha fetoprotein(AFP),abnormal prothrombin(PIVKA-II)and vascular endothelial growth factor(VEGF)in the clinical diagnosis of hepatocellular carcinoma.Methods:The study adoped a single blind method.Continuously collected from December 2016 to June 2017,170 patients with liver-occupied patients who were diagnosed by imaging in the Affiliated Tumor Hospital of Xinjiang Medical University were selected as subjects.The final diagnosis of hepatocellular carcinoma or non-hepatocellular carcinoma was confirmed by gold standard of pathological tissue.The levels of serum AFP.PIVKA-II and VEGF were detected by chemiluminescence microparticle immunoassay(CMIA)and enzyme-linked immunosorbent assay(ELISA),respectively.Then draw the receiver operating characteristic curve(ROC curve)and analyze the difference between single and combined diagnosis of hepatocellular carcinoma(HCC).Results:The serum levels of AFP、PIVKA-II and VEGF in hepatocellular carcinoma patients were significantly higher than that of non HCC group(Mann-Whitney U value was 2001.000,1744.000,2434.500,Z value was-5.018,-5.819,-3.666,and P <0.001 respectively),which were statistical significance.The areas under the ROC curve of serum AFP,PIVKA-II and VEGF were 0.723,0.758 and 0.663,respectively.A separate test,The sensitivity of AFP,PIVKA-II,and VEGF in the diagnosis of hepatocellular carcinoma was 55.200%,81.600%,and 64.400%,respectively.The specificities were 86.700%,74.700%,and 62.700%,respectively.During joint detection,AFP + PIVKA-II,AFP + VEGF,PIVKA-II + VEGF,AFP+PIVKA-Ⅱ+VEGF diagnosis of hepatocellular carcinoma sensitivity were 85.060%,82.760%,93.100%,97.700%;specificity was 65.060%,54.220%,48.190%,45.780%.Conclusion:Serum AFP,PIVKA-II,and VEGF have certain diagnostic value for patients with hepatocellular carcinoma.Compared with the three tests alone,combined detection can significantly increase sensitivity and improve diagnostic efficiency.It is of great clinical significance for the early diagnosis of hepatocellular carcinoma. |
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