| Objective:This experiment analyzed and summarized the mentor’s clinical experience in the treatment of recurrent spontaneous abortion with traditional Chinese medicine before pregnancy,objectively evaluated the clinical efficacy of pre-pregnancy intervention with traditional Chinese medicine,recognized the advantages of pre-pregnancy prevention combined with post-pregnancy placenta in comparison with post-pregnancy placenta alone,improved the success rate of post-pregnancy placenta in patients with recurrent spontaneous abortion,provided effective and practical ideas and methods for clinical treatment.Methods:A total of 75 cases of recurrent spontaneous abortion were collected according to the diagnostic criteria and inclusion criteria.They were divided into treatment group(pre-pre intervention group)and control group(non-pre-pregnancy intervention group)according to whether traditional Chinese medicine was used before pregnancy.After pregnancy,they treated with combination of traditional Chinese and Western medicine and placebo.Observe the success rate of fetal preservation after treatment in two groups,evaluate the score of TCM symptoms during the next pregnancy,monitor the maternal serum sex hormone levels(E2,P,beta-HCG).pelvic B-ultrasound and other related indicators(thyroid function,lymphocyte immune analysis).Results:(1)Pregnancy outcome comparison:The total effective rate was 84.21%in the treatment group of 38 cases,including 32 cases of continuing pregnancy,5 cases of em sterilization and 1 case of ectopic pregnancy.The total effective rate was 62.16%in the control group of 37 cases,including 23 cases of continuing pregnancy,11 cases of embryo sterilization and 3 cases of ectopic pregnancy.The curative effect of the treatment group was better than of the control group.(2)It was found that the proportion of symptoms in the treatment group 86.84%and 13.16%respectively,while that in the control group was 67.57%and 32.43%respectively.There were no severe cases in the two groups,and the difference of symptoms was statistically significant(P<0.05).(3)Comparison of serum sex hormones:Serum sex hormone comparison:The levels of E2,P and beta-HCG in peripheral blood of the two groups increased with the increase of pregnancy.The levels of serum E2,P and beta-HCG in the treatment group were higher than those in the control group at 6,8 and 10 weeks of gestation(P<0.05).(4)Thyroid function comparison:The detection rate of TSH>2.5mIU/L in the treatment group was not significantly different from that in the control group,but the inci of adverse pregnancy in the treatment group(19.05%)was significantly lower than that in the control group(45.00%).(5)Serum lymphocyte immunoassay:At 6 weeks of gestation and 10 weeks of gestation,the percentage of CD4+cells in the treatment group was significantly lower than that in the control group,and the percentage of CD8+ cells in the treatment group was significantly higher than that in the control group,with statistical significance(P<0.05).Conclusion:Pre-pregnancy Chinese medicine conditioning can effectively improve the success rate of pregnancy protection in patients with recurrent abortion,and its efficacy is better than that of simple post-pregnancy placebo treatment.Pre-pregnancy prevention and treatment of recurrent spontaneous abortion with periodic therapy and differentiation of symptoms and signs can significantly improve the symptoms and signs of re-pregnancy,with definite clinical effect.Pre-pregnancy Chinese medicine conditioning can reduce the early abortion rate and avoid adverse pregnancy outcomes by improving the sex hormone level,thyroid function and immune tolerance of pregnant women. |
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