Clinical Study Of Yiqi Gubiao Pill In Delaying The Progression-free Survival Of EGFR-TKI,a Targeted Drug For Non-small Cell Lung Cancer

OBJECTIVE: To study the time-consuming time of oral targeted drug TKI in patients with non-small cell lung cancer treated with Yiqi Gubiao Pill.Method:A total of123 patients with non-small cell lung cancer(NSCLC)hospitalized in our hospital from January 2018 to December 2018 were selected.all patients were diagnosed as NSCLC by percutaneous lung biopsy.Gene detection showed that EGFR gene mutation was positive,and the patients were treated with a generation of targeted drugs for at least 6 months.the patients were randomly divided into two groups: the experimental group(n=30)and the control group(n= 33).The patients in the experimental group were treated with targeted drugs plus Yiqi Gubiao pills,while those in the control group were treated with single targeted drugs.both groups were treated with targeted drugs regularly for a long time until the patient progressed.The experimental group was treated with Yiqi Gubiao pills orally for 3 months,and the difference between the two groups was evaluated by comparing the time of disease progression,quality of life and adverse reactions between the two groups.Result:1.The PFS of patients with advanced NSCLC treated with Yiqigubiao pills combined with targeted drugs was longer than that of patients treated with targeted drugs alone(P < 0.05).The PFS of the experimental group was 12.23 months,while that of the control group was 9.56 months,the difference was statistically significant.2.The combined treatment group was better than the control group in improving the quality of life in the treatment of advanced non-small cell lung cancer(P < 0.05).The improvement rate was 83% in the experimental group and 58% in the control group,the difference was statistically significant.3.In the treatment of advanced NSCLC,the incidence of rash was23.33% in the experimental group and 33.33% in the control group(P > 0.05).There was no significant difference between the two groups.Conclusion:1.Yiqigubiao pills combined with targeted drugs can prolong PFS in patients with advanced non-small celllung cancer(NSCLC).2.Traditional Chinese medicine Yiqi Gubiao pills combined with targeted drug therapy can significantly improve the living conditions of patients.3.Yiqi Gubiao Pill has no obvious curative effect on adverse reactions caused by targeted drugs,such as rash and diarrhea.