Clinical Characteristics And OCT Analysis Of AQP-4 And MOG Antibody Positive NMOSD

Objective:To investigate the clinical characteristics and retinal damage in two different antibody NMOSD patients.Methods:Retrospectively collected 15AQP-4 antibody positive NMOSD patients and 12 MOG antibody positive NMOSD patients from the People's Hospital of Xinjiang Uygur Autonomous Region.The clinical data of age,sex,course of disease,core clinical symptoms and recurrence times were recorded in detail.At the same time,15 healthy controls matched by age and sex were selected.The retinal nerve fiber layer was measured by OCT at 12 hours in NMOSD group and control group.The retinal nerve fiber layer was compared and analyzed at at each hour between case group and healthy control group,AQP-4 antibody positive NMOSD group and MOG antibody positive NMOSD group.Results:1.Compared with AQP-4 antibody positive NMOSD group,MOG antibody positive NMOSD group was more prone to optic nerve involvement(?~2=6.075,P=0.014).Spinal cord involvement was more likely in AQP-4 positive NMOSD group than in MOG positive NMOSD group(?~2=4.201,P=0.04).2.The retinal nerve fiber layer thickness of NMOSD patients at 1 o'clock,6 o'clock,7 o'clock,8 o'clock,9 o'clock,10 o'clock,11o'clock and 12 o'clock was thinner than normal control group(P<0.05);3.The retinal nerve fiber layer thickness of AQP4 antibody positive NMOSD and MOG antibody positive NMOSD group was thinner than normal control group at 6hours(P<0.05).The retinal nerve fiber layer thickness of AQP4 antibody positive NMOSD group was significantly different from MOG antibody positive group only at 9 o'clock and 12 o'clock(P<0.05).Conclusions:MOG antibody positive NMOSD was more prone to optic nerve involvement,while AQP4antibody positive NMOSD was more prone to spinal cord involvement.Both AQP4 antibody positive NMOSD and MOG antibody positive NMOSD can cause severe retinal axon injury;the retinal damage of MOG antibody positive NMOSD is less severe than that of AQP4 antibody positive NMOSD.