Research About Influence Factors On The Thickness Of Retinal Nerve Fiber Layer In The Neuromyelitis Optica Spectrum Diseases

Objective: To explore the frequency of optic neuritis(ON),the use of different immunoregulatory drugs and the types of antibodies on how to change retinal microstructure in patients with neuromyelitis optica spectrum disorders(NMOSD),and to provide preliminary guidance ON when and how to use the medicine.Methods: Clinical data of 58 cases of NMOSD patients and 20 cases of normal control group treated in the department of neurology of the First hospital of Shanxi Medical University from February 2018 to September 2019 were retrospectively collected.Among the 58 patients,38 were aqp-4 antibody positive and 20 were aquaporin-4 antibodies negative.Optical coherence tomography(OCT)was used to detect the thickness of retinal nerve fiber layer(RNFL),and the effects of the frequency of ON,the use of different immunoregulatory drugs and the types of antibodies were analyzed and compared.Results: 1.Compared with the control group: RNFL thickness in all the quadrants in NMOSD patients decreased,the difference was statistically significant(p<0.05);RNFL thickness in all the quadrants in aquaporin-4 antibodies positive group decreased,the difference was statistically significant(p<0.05).The RNFL thickness in the temporal quadrant in aquaporin-4 antibodies negative group decreased,the difference was statistically significant(p<0.05).2.The relationship about the frequency of ON: alterations of RNFL thickness are not the same as the number of ON attacks(p<0.05).The alterations in patients on the first ON attack was greater than that in the second,third,and fourth ON attacks.The difference was statistically significant(p <0.05).3.The RNFL thickness might increase with different kinds of drugs in remission period separately,the difference was statistically significant(p<0.05).The RNFL thickness of patients receiving AZA,MMF and TCZ separately increased slightly,the difference was statistically significant(p<0.05).4.The comparison between positive and negative aquaporin-4 antibodies: The inferior,and temporal quadrant and mean RNFL thickness of the seropositive patients group were thinner than that in the seronegative patients group.The difference was statistically significant(p<0.05).Conclusion: 1.The RNFL thickness decreased in all ON eyes of NMOSD patients,the RNFL thickness of ON eyes decreased more sharply in the first episode,and the application in AZA,MMF and TCZ may increase the RNFL thickness.2.The inferior,temporal quadrant and mean RNFL thickness of NMOSD patients in the aquaporin-4 antibodies positive group were thinner than that in the negative group.