Effect Of Atorvastatin On The Treatment Of Acute Coronary Syndrome And Its Effect On Serum Inflammatory Factor Levels

Objective: To study the effect of medium dose atorvastatin in the treatment of acute coronary syndrome and its effect on serum inflammatory mediators,and to provide a reference for clinical treatment of acute coronary syndrome.Methods: 172 patients with acute coronary syndrome from department of cardiology,Pidu district people’s hospital,from January 2016 to June 2018 were selected.according to random number table is divided into the control group(86 cases)and group(86 cases).Both groups of patients with acute coronary syndrome were given conventional treatment.The control group was treated with 20 mg atorvastatin calcium tablets based on conventional treatment,and the research group was treated with 40 mg atorvastatin calcium tablets based on conventional treatment.Compared two groups before treatment and 1,2,3 months after treatment blood lipid(total cholesterol,low density lipoprotein cholesterol,high-density lipoprotein cholesterol,triglycerides),blood glucose,fasting blood glucose,blood sugar 2 hours after meal,glycosylated hemoglobin),kidney function(endogenous creatinine clearance,urine trace albuminuria/creatinine ratio),liver function(blood Alt,total bilirubin,direct bilirubin blood,blood blood indirect bilirubin),serum inflammatory mediators(high-sensitivity c-reactive protein(CRP)and interleukin-18(IL-18),matrix metalloproteinases 9(MMP-9),nitric oxide(NO)and the changes of Incidence of adverse reactions to treatment.Results: 1.The levels of total cholesterol,low-density lipoprotein cholesterol and triglyceride in study group and control group before treatment showed no significant difference(P > 0.05).After treatment,levels of total cholesterol,LDL cholesterol and triglyceride in study group were significantly lower than those in the control group,with statistically significant differences(P < 0.05).There was no significant difference in HDL cholesterol level between the two groups before treatment(P > 0.05).After treatment,the HDL cholesterol level in the study group was significantly higher than that in the control group,and the difference was statistically significant(P < 0.05).3.There was no difference in fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,endogenous creatinine clearance,urinary microalbumin/urinary creatinine,alanine transaminase,total blood bilirubin,direct bilirubin and indirect bilirubin between the study group and the control group before and after treatment,with no statistical significance(P > 0.05).4.There was no significant difference in the levels of hypersensitive c-reactive protein,interleukin-18 and matrix metalloproteinase-9 between two groups before treatment(P > 0.05).After treatment,levels of high-sensitivity c-reactive protein,interleukin-18 and matrix metalloproteinase-9 in study group were significantly lower than those in the control group(P < 0.05).5.There was no significant difference in the level of nitric oxide between the two groups before treatment(P > 0.05).After treatment,the level of nitric oxide in the study group was significantly higher than that in the control group,and the difference was statistically significant(P < 0.05).6.There was no significant difference in the incidence of adverse reactions after treatment between the two groups(P > 0.05).Conclusion: 1.Medium dose of atorvastatin could reduce blood lipid,inflammatory factors,and increase the synthesis of NO in vascular endothelial cells,which could be more helpful to stabilize atherosclerotic plaques,improve vascular endothelial function,and reduce the occurrence of cardiovascular events.2.In the treatment of acute coronary syndrome with medium dose atorvastatin,there was no significant increase in the common adverse reactions,and the drug safety was better.