| Objective: to investigate the diagnostic value of platelet-to-lymphocyte ratio(PLR),glutamyl transferase(GGT)and albumin in opportunistic infection.of HIV/AIDS patientsMethods:collected the clinical data of patients confirmed to be HIV-1 antibody positive in Guangxi Longtan Hospital from June 2016 to June 2018.A healthy control group(497 cases)was set up,and HIV-1 antibody positive patients(disease group)were divided into an opportunistic infection proup(763cases)and an non-opportunistic infection group(179 cases).On the basis of different etiology,opportunistic were divided into bacterial infection group,fungal infection and mixed infection group,bacterial infection group will be divided into mycobacterium group(group A),mycobacterium+ the other bacteria group(group B),the other bacteria group(except mycobacterium)(group C),fungal infection group was divided into talaromyces marneffei group(group D),candida group(group E),talaromyces marneffei group+ candida group(group F).Detection of each group of PLR?GGT and ALB,compare diseases group and healthy controls,opportunistic infection proup and non-opportunistic infection group,bacterial infection group with fungal infection and mixed infection group,group A with group B and group C,group D with group.E and group F,then explore their value in the early diagnosis of HIV/AIDS opportunistic infection.Results:PLR was higher in the HIV/AIDS group than in the healthy control group(P < 0.05),in the opportunistic infection group than in the non-opportunistic infection group(P < 0.05),in the mixed group than in the fungal group(P < 0.05),in the fungal group than in the bacterial group(P <0.05),in the group F than in the group D(P < 0.05),and in the group D than in the group E(P < 0.05).There was no significant difference between group A and B,between group B and C,or between group A and group C.GGT was higher in the HIV/AIDS group than in the healthy control group(P < 0.05),in the opportunisticinfection group than in the non-opportunistic infection group(P <0.05),in the bacterial group than in the mixed group(P < 0.05),in the mixed group than in the fungal group(P < 0.05),in the group C than in the group B(P<0.05),in the group B than in the group A(P < 0.05),in the group D than in the group F(P < 0.05),and in the group F than in the group E(P < 0.05).ALB in the group of patients with HIV/AIDS is relativelylower than healthy controls(P <0.05),in the opportunistic infection group was lower than those of noopportunistic infection group(P < 0.05),in mixed group was lower than those of bacteria group(P < 0.05),lower in the group of bacteria from fungal(P <0.05),in group C was lower than those of group B,lower in group B thanin group A(P < 0.05),in the D group was lower than those of group F,in group F was lower than those of group E(P < 0.05).ROC curve to determine the PLR determine HIV/AIDS merged the total of opportunistic infections in patients with critical value is 208.69(0.614 area under the ROC curve,sensitivity54.6%,specificity 65.9%),judgement of PLR HIV/AIDS merger fungal opportunistic infections in patients with critical value is 208.14(0.613 area under the ROC curve,sensitivity 54.9%,specificity 65.4%),judgement of PLR HIV/AIDS patients with talaromyces marneffei and candida mixed infection of critical value is 250.55(0.648 area under the ROC curve,sensitivity53.1%,specificity 72.6%),the critical value of PLR for HIV/AIDS patients with talaromyces marneffei is 270.01(area under the ROC curve0.611,sensitivity50.0%,specificity 77.1%).The critical value of GGT for HIV/AIDS patients with the other bacterial infection was 60.50(area under the ROC curve was0.635,sensitivity was 45.8%,specificity was 82.0%).GGT combined with NEU%determined that HIV/AIDS patients combined with the other bacterial infection,the area under the ROC curve was 0.715,sensitivity was 70.8% and specificity was 74.2%.The area under ROC curve determined by ALB for HIV/AIDS patients with opportunistic infection was 0.330(< 0.5).ALB determined that the area under ROC curve of HIV/AIDS patients with bacterial opportunistic infection was 0.348(< 0.5).ALB determined the ROC area of HIV/AIDS patients with fungal opportunistic infection to be 0.351(<0.5).The area under ROC curve of HIV/AIDS patients with mixed opportunistic determined by ALB was 0.306(<0.5).ALB determined that the ROC area of HIV/AIDS patients infected with talaromyces marneffei was 0.250(<0.5).The ROC curve of ALB in HIV/AIDS patients with mixed infection of talaromyces marneffei and candida was 0.353(<0.5).Conclusion: 1.PLR is of certain value for the determination of HIV/AIDS patients combined with total opportunistic infection,combined with fungal opportunistic infection,combined with talaromyces marneffi and candida mixed infection,and combined with talaromyces marneffi infection.2.GGT and GGT combined with NEU% are of certain value for the determination of HIV/AIDS patients combined with other bacterial infections except mycobacterium.3.ALB is not suitable for the analysis of HIV/AIDS patients with opportunistic infection. |
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