Comparison Of The Therapeutic Effects Of Two Negative Pressure Wound Modes On Diabetic Foot Ulcer

Objective:To compare the therapeutic effects of two negative pressure wound treatment modes on percutaneous oxygen partial pressure,ulcer area and ulcer granulation tissue in the peripheral tissues of diabetic foot ulcerMethods: Sixteen patients with diabetic foot ulcer admitted to our department from April 2018 to August 2018 were selected.After comprehensive systemic treatment,wound evaluation and debridement,patients with wound bed suitable for negative pressure wound treatment were using randomly grouped,opened,parallel and crossed method.Even arrays received 1 week of vacuum assisted closure(VAC)treatment,and then received 1 week of vacuum closed drainage(VSD)treatment.The odd array was first treated with VSD for 1week and then treated with VAC for 1 week.The patients' foot ulcer wounds were photographed before treatment,at the end of 1 week of treatment,and at the end of the second week of treatment.Image J software was used to analyze changes in ulcer area and granulation tissue area,and the Denish ray percutaneous oxygen partial pressure meter was used.The transcutaneous oxygen pressure at two sites around the ulcer before treatment,at the end of the first week of treatment,and at the end of the second week of treatment weremeasured.Results:(1)At the end of 2 weeks of treatment,the area of ulcer in both groups decreased compared with that before treatment,while the area of granulation and percutaneous oxygen partial pressure increased compared with that before treatment,and the difference was statistically significant(P < 0.05).(2)The two different negative pressure treatment modes of VSD and VAC at the end of each treatment had statistically significant changes in the transcutaneous oxygen pressure,ulcer area and granulation tissue area of the subjects(P < 0.05).and the numerical of percutaneous oxygen partial pressure increase,ulcer reduction area and granulation tissue increase area in the VAC group were larger than those in the VSD group.(3)No matter which negative pressure treatment mode was adopted,the increase value of percutaneous oxygen partial pressure after the first week of treatment was greater than that after the second week of treatment,and the difference was statistically significant(P < 0.05).Conclusion:(1)VAC and VSD,two negative pressure treatment modes,can both promote the reduction of wound surface of diabetic foot ulcer,granulation tissue growth and increase oxygen partial pressure of ulcer tissue to some extent,so as to promote wound healing.(2)VAC is superior to VSD in reducing the area of diabetic foot ulcer,increasing the area of granulation tissue on the wound surface and improving the oxygen partial pressure of the surrounding tissues,indicating that VAC treatment mode has more advantages in the treatment of diabetic foot ulcer.(3)In the first stage of wound treatment,both VSD and VAC can achieve the effect of wound drainage and reduce edema of surrounding tissues of ulcer.