| Perimenopausal syndrome(PMS)is commonly referred to as "climacteric syndrome(MPS)".In 1994,the World Health Organization proposed to discontinue the name of the disease and change it to "perimenopausal syndrome".However,Chinese people have long been accustomed to the name of "climacteric syndrome",so "climacteric syndrome" has been used up to now.The ovary is the first organ of the human body to completely senile and lose all its functions.Research shows that human life expectancy increases with the improvement of medical level,and women’s life will continue for about 30 years after menopause.During this period,due to the serious lack of estrogen,leading to a series of symptoms.In order to improve the quality of life and happiness index of the vast majority of women,it is necessary to find effective and safe therapies to treat the disease.Bushen Heying Decoction is the specialty of treating perimenopausal syndrome,which is based on the clinical experience of Professor Wang Jiawei for more than ten years.It combines kidney tonifying with Yingwei harmonizing organically.The clinical effect is remarkable,especially in improving the hot flashes and sweating,facial flushing of patients.Compared with hormone replacement therapy,it has a wide range of application,fewer contraindications,high safety andignorance.It has obvious side effects and is worthy of clinical application.OBJECTIVE: To observe the clinical efficacy,improvement rate and safety of Bushen Heying Decoction in the treatment of perimenopausal syndrome,and to explore its research background,pathogenesis and pharmacological research,so as to provide observation and new ideas for the treatment of perimenopausal syndrome,and to provide basis for clinical popularization and application.Methods: A control group of Fenmotong was set up in this study.The cases were recruited from the clinic of famous doctors of Wuhan Traditional Chinese Medicine Hospital from October 2017 to June 2018.Sixty-seven perimenopausal syndrome patients who met the inclusion criteria were selected.They were divided into 35 cases of Bushen Heying Decoction treatment group and 32 cases of Fenmotong control group for one course of treatment.Before and after treatment,the scores of TCM symptoms,the total effective rate of TCM symptoms,the total effective rate of single TCM symptoms and the Kupperman score were observed.The clinical efficacy,endocrine effects and safety of the two therapies were observed by using statistical software SPSS25.0 data analysis and processing.Results:(1)Before treatment,there were no significant differences in the general conditions of the treatment group and the control group(P > 0.05),such as age,duration of disease,Kupperman symptom score,TCM syndrome score,liver and kidney function,three routines,electrocardiogram,breast color Doppler ultrasound,etc.(P>0.05).(2)After treatment,the scores of TCM syndromes and Kupperman symptoms in the treatment group and the control group were lower than those before treatment,with statistical significance compared with those before treatment.(3)After treatment,the single clinical symptoms of the treatment group and the control group were improved compared with those before treatment,with statistical significance compared with those before treatment,especially the symptoms of menstrual disorders,flushing,hot flashes and night sweats.The treatment group Bushen Heying Decoction can significantly improve the symptoms of hot flashes,night sweats and flushing complexion in patients with perimenopausal syndrome,and due to hormone supplementation therapy in the control group.(4)After treatment,the E2 level in the treatment group and the control group were higher than before treatment,and the values of FSH and LH were lower than before.The results showed significant difference(P < 0.05),but there was no significant difference between the two groups(P > 0.05).CONCLUSION: Bushen Heying Decoction is superior to Fenmotong in reducing TCM syndrome score,Kupperman score and alleviating clinical symptoms in treating perimenopausal syndrome compared with hormone supplementation alone.It can also significantly improve E2 level in patients with perimenopausal syndrome,improve symptoms such as flushing,hot flashes and sweats,delay ovarian recession,regulate endocrine and plant growth.Neurology,with good safety,no obvious toxic and side effects,has definite curative effect.It provides a certain clinical basis for the treatment of perimenopausal syndrome by traditional Chinese medicine,and can be further studied. |
