| ObjectiveBy using MRS and Q-Space imaging technology,the imaging characteristics of white matter fibers in primary motor cortex and posterior limbs of subcortical internal capsule in Parkinson’s disease patients with motor disorder were analyzed,and the correlation between the changes of axonal function and structure in cerebral cortex and subcortical cortex and motor disorder was further revealed.MethodThe motor function and clinical condition of 20 patients with Parkinson’s disease were assessed by the third part of the Unified Parkinson’s Scale.and H&Y Parkinson’s Clinical Staging Scale.MR scanning was performed with ~1H-MRS,and the image was processed.The peak maps of N-acetylaspartic acid(NAA),choline(Cho)and creatine(Cr)in the region of interest(the primary motor area of the central anterior gyrus of the cerebral cortex,i.e.M1 region)were obtained,and the ratios of NAA/Cr and Cho/were calculated.Then Q-Space MR diffusion imaging technology was used to collect Q-Space images,and DSI-studio workstation was used to post-process the images.The FA,GFA and ADC parameters of Q-space in the primary motor cortex and the region of interest in the posterior limb of internal capsule were obtained.Then,the parameters of MRS and Q-Space in the experimental group and the control group were further analyzed by SPSS statistical software.ResultAfter assessing with Parkinson’s Score Scale,there were obvious motor dysfunction in the experimental group.The average clinical stage of H&Y was 3.0±.31.In the analysis of MRS data,the ratio of NAA/Cr in the primary motor area of the anterior central gyrus in the experimental group was significantly lower than that in the control group(P<0.05).In the ADC map obtained by Q-space imaging technology,the ADC value in the primary motor area of the anterior central gyrus in the experimental group was higher than that in the control group(P<0.05),and the difference was statistically significant(P<0.05).There was no significant difference between the experimental group and the control group(P>0.05)in the FA and GFA values of the posterior limb of the capsule to characterize the characteristics of white matter fibers.ConclusionIn Parkinson’s patients with motor dysfunction,there were obvious functional and structural changes in the primary motor area neurons and peripheral white matter of the anterior central gyrus,and no obvious damage to the axonal structure of the descending fibers in the cortex. |
