| Objective: To determine the severity of bronchiectasis by using the FACED and BSI scores in patients with bronchiectasis,and to analyze the correlation between the two scores and CD3+,CD4+,CD8+ T lymphocyte counts,as well as CD4/CD8,so as to determine the role of cellular immunity in bronchiectasis.Methods: 142 patients who were explicitly diagnosed as bronchiectasis in the department of respiratory medicine of the first hospital of Jilin university from September 2016 to December 2018 were selected,and 27 patients who underwent physical examination in the physical examination center of Jilin university from September 2016 to January 2019 were selected.Age,sex,smoking history,history of alcohol use,diabetes mellitus,dyspnea,lung function,number of hospitalizations due to bronchiectasis,and the number of pulmonary lobes associated with bronchiectasis as indicated by CT were calculated for all patients.Cellular immunity was collected from all the selected patients.SPSS22.0 was applied to conduct a comparative analysis on the general data characteristics of patients with bronchiectasis,and the correlation between each factor and the severity of bronchiectasis was calculated.At the same time,the correlation between the FACED score and the BSI score was analyzed,so as to analyze the role of cellular immunity in bronchiectasis.Results:(1)The age(p=0.061),gender(p=0.096),smoking history(p=0.672),drinking history(p=0.984)and diabetes mellitus(p=0.615)of the patients with bronchiectasis and the control group showed no statistical difference.(2)The severity of bronchiectasis was correlated with the patient’s age(p=0.010),lung function(p<0.001),pseudomonas aeruginosa colonization(p=0.001),and the number of involved pulmonary lobules(p < 0.001).(3)The cell counts of CD4+ and CD8+ in patients with bronchiectasis were lower than those in the control group(p=0.028,0.049),with statistically significant differences,while there was no significant difference in CD3(p=0.192)and CD4/CD8(p=0.589)between the two groups.(4)Correlation analysis of the patients’ FACED and BSI scores with CRP,WBC and NE% showed no correlation between the severity of bronchiectasis and the total number of white blood cells(p=0.878,0.963),Neutrophil percentage(p=0.117,0.128)and CRP(p=0.348,0.228).(5)A comparative analysis of the patients with FACED and BSI and cellular immunity showed that CD4 was correlated with FACED(r=-0.173,p=0.040)and BSI(r=-0.160,p=0.048).There was no correlation between CD3 and FACED(r=-0.106,p=0.209)and BSI(r=-0.089,p=0.292),between CD8 and FACED(r=-0.360,p=0.668)and between CD4/CD8 and FACED(r=-0.076,p=0.368).Conclusion:(1)The cell counts of CD4+ and CD8+ in patients with bronchiectasis were lower than those in the control group,considering that T lymphocyte helper cells and cytotoxic T lymphocytes play a role in bronchiectasis.(2)FACDE score and BSI score in patients with bronchiectasis were correlated with CD4+ cell counts.With the aggravation of the severity of bronchiectasis,the lower the cell count of cellular immunity was,and it was important to infer that CD4+ T lymphocytes play an important role in bronchiectasis.(3)Peripheral blood white blood cell count,neutrophil percentage and CRP were not correlated with the severity of bronchiectasis,and the possibility of acute infection was suggested by the increased values,which could not reflect the severity of bronchiectasis. |
