Changes Of Serum Tenascin-C Level In Children With Kawasaki Disease And Its Clinical Significance

Objective:To ensure whether peripheral blood Tenascin-C can as a novel predictor for coronary artery lesion by comparing peripheral blood Tenascin-C level among on admission,after treatment and recovery in children with Kawasaki disease and comparing Tenascin-C level among Kawasaki disease,anaphylactoid purpura,infectious mononucleosis patients and healthy control.Methods:Peripheral blood TN-C level was measured in children with KD,anaphylactoid purpura,infectious mononucleosis patients or healthy during January 1,2018 and November 1,2018.Then statistically analyzed and compared.Results:We collected blood samples of 44 KD patients(CAL~+:21;CAL~-:23),39 anaphylactoid purpura patients,24 infectious mononucleosis patients and 36 healthy controls were enrolled.The study found TN-C levels on admission and after treatment were significantly higher in patients than in patients during convalescence after IVIG administration(32.0±13.8,33.5±11.4,23.3±10.8ng/ml,respectively;P<0.05),and correlated positively with C-reactive protein(P=0.038),and negatively with sodium level(P=0.004).But there was no statistically significant difference in TN-C level between CAL~+and CAL~-(on admission:31.7±15.4 vs 32.3±12.5ng/ml;after IVIG treatment:32.2±11.6vs 34.8±11.3ng/ml;convalescence:22.6±7.3vs24.0±13.4ng/ml;P>0.05,respectively).In addition,TN-C level with KD,.anaphylactoid purpura and infectious mononucleosis were higher than healthy children(32.0±13.8,37.2±18.2,56.6±23.1,24.0±8.05ng/ml,respectively,P<0.05).Conclusion:This study was not sufficient to prove that peripheral blood TN-C can be used as a novel predictor for coronary artery lesion in KD,nor can it be used as a maker of vascular injury,but it may be used as an indicator of immune response in the acute phase of Kawasaki disease.In addition,this study was the first to find that TN-C was increased in infectious mononucleosis.