Evaluation Of Islet Beta-cell Function In Type 2 Diabetes Mellitus By Urinary C-peptide/creatinine Ratio

Objective To explore the application of single urinary C-peptide/creatinine ratio(UCPCR)in assessing the function of islet beta cells in patients with type 2diabetes(T2DM).Methods Urinary C-peptide,urinary creatinine,fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide were measured in patients with T2 DM and healthy controls respectively.The correlation between UCPCR and fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,fasting blood C-peptide,2-hour postprandial blood C-peptide and 24-hour urinary C-peptide was analyzed.Results1.Compared with the normal control group,fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin were significantly increased in type 2 diabetic patients,the difference was statistically significant(P<0.05),2-hour postprandial blood C-peptide,24-hour urine C Peptide and urinary C-peptide/creatinine were decreased,the difference was statistically significant(P<0.05),and fasting blood C Peptide was decreased,but the difference was not statistically significant(p>0.05).2.Pearson correlation analysis showed that urinary C-peptide/creatinine in type 2diabetic patients had a significant positive correlation with 24-hour urinary C-peptide(r=0.583),fasting blood C-peptide(r=0.358),and 2-hour postprandial blood C-peptide(r=0.675)(P<0.05),and a significant negative correlation(P<0.05)with fasting blood glucose(r=-0.261),2-hour postprandial blood glucose(r=-0.372),and glycosylated hemoglobin(r=-0.492).Among them,urinary C-peptide/creatinine was more strongly correlated with 2-hour postprandial blood C-peptide(r=0.675).3.Pearson correlation analysis showed urinary C-peptide/creatinine ratio had no relationship with age(r=-0.131 P>0.05,)and eGFR(r=-0.109,P>0.05),but had a significant negative correlation with the course of disease(r=-0.338)(P<0.05).There was no significant difference in urinary C-peptide/creatinine ratio between different genders(P>0.05),Conclusion Urine C-peptide/creatinine ratio can be used to assess islet ?-cell function in patients withtype 2 diabetic patients.The method is simple in operation,reproducibl easy to be applied in clinical practice.