Study On The Relationship Between Urinary C - Peptide / Creatinine Ratio And 24 - Hour Urinary C - Peptide And Islet β - Cell Function In Type 2 Diabetic Patients

Objective To investigate relationship of a single sample urinary C-peptide/creatinine rate(UCPCR) and24-h urinary C-peptide(UCP) with islet β-cell function in type2diabetic patients. Methods Ninety type2diabetic patients(T2DM group) and thirty health volunteers (NC group) were enrolled for this study, blood C-peptide, insulin, blood glucose, first void fasting UCPCR, second void fasting UCPCR,24-h UCP were determined. Homeostasis model assessment was used to evaluate islet β-cell function. glomerular filtration rate(GFR) were measured by99TCm-DTPA renogrophy. Results (1) There were no significant differences in sex, age, body mass index (BMI) and waist hip ratio (WHR) with the baseline between the two groups (P>0.05), this study is comparable. Fasting blood glucose (FBG) and fasting insulin (FINS) in T2DM group were higher than that in NC group (P<0.05).(2) Insulin secretion index in T2DM group was lower than that in NC group (P<0.01), and there were no significant differences in the glomerular filtration rate(GFR)(P>0.05), first UCPCR and second UCPCR between the two groups (P>0.05). Second void fasting UCPCR is significantly lower than first UCPCR in T2DM group and NC group [0.84(0.42～1.35) vs1.18(0.52-1.96), P<0.01;0.90(0.42～1.92) vs1.34(0.59～1.98), P<0.05)], respectively.24-h UCP in T2DM group was higher than that in NC group (P<0.05).(3)The results show that second void fasting UCPCR and first void fasting UCPCR were positively related to24-h UCP(P<0.01), and were also high related to the index of islet β-cell function (P<0.01). Conclusions second void fasting UCPCR was higher related to24-h UCP in type2diabetic patients and the method was simple and it was also related to insulin secretion index, can noninvasively evaluate islet β-cell function. it has a certain clinical practical value.