The Relationship Between Skeletal Muscle Mass And Non-alcoholic Fatty Liver Disease

Aim: investigate the relationship between skeletal muscle mass loss and nonalcoholic fatty liver(NAFLD)to provide a new evidence for clinical treatment of non-alcoholic fatty liver disease..Methods: MRS or Fibroscan or liver biopsy were detected in patients with NAFLD who were screened by ultrasound in the Department of Gastroenterology of Sichuan Provincial people's Hospital from December 2017 to February 2019,41 patients were confirmed by the above methods,and excluded fatty liver caused by other causes.Another 14 volunteers were recruited to rule out fatty liver by Fibroscan.examined the anthropometric index,serological index and body compositionby of the above 55 subjects for Cross-sectional analysis.The independent risk factors of NAFLD were determined by a binary logisitic regression analysis after adjust the fat muscle ratio,TT4,HDL,TG,ALT,AST,hsCRP,BMI and HOMA-IR.Results: Among the 55 subjects included in the study,the prevalence of NAFLD was 74.55%(41 / 51).Compared with the normal group,the NAFLD group had a lower skeletal muscle mass index(P = 0.004).HDL level(P = 0.004)and TT4 level(P = 0.015);Spearman correlation analysis showed that there was a negative correlation between skeletal muscle mass index and NAFLD(r = 0.455,P< 0.001);Under the control of muscle fat ratio of confounding factors,the SMI value was excluded from the equation when the binary logisitic regression analysis was established after TT4,HDL,TG,ALT,AST,hsCRP,BMI and HOMA-IR(P> 0 05).Conclusion: 1)There was a negative correlation between skeletal muscle mass index(SMI)and nonalcoholic fatty liver,but SMI was not an independent risk factor of nonalcoholic fatty liver disease;2)insulin resistance and hypersensitive C-reactive protein were the independent risk factor non-alcoholic fatty liver disease;3)There was a negative correlation between Serum Total thyroxine(TT4)and nonalcoholic fatty liver disease.