| Cancer-related fatigue(CRF)is a cormon debilitating symptom among cancer survivors,which seriously impairs the functional independence and quality of life of patients.Cancer patients are deficient in vital energy,the discord between yin and yang,combined with surgery,radiotherapy and chemotherapy can lead to the deficiency of viscera,Qi and blood,and the worsening of mental fatigue.The development of the whole disease should be based on deficiency syndrome and empirical evidence.On the basis of insufficient positive qi,the weakness of spleen and stomach is more obvious in gastric cancer CRF.Therefore,the treatment of CRF for gastric cancer should pay more attention to invigorating the spleen,invigorating qi and nourishing the stomach,strengthening the body's health and resisting pathogens,and improving the body's imimunity.The elderly patients with gastric cancer often suffer from severe fatigue due to the growth of age,organ function deterioration,and the use of chemotherapeutic drugs aggravates the fatigue of elderly patients with gastric cancer,which reduces the chemotherapeutic sensitivity and drug tolerance of patients and forms a vicious circle,making it more difficult for patients to adhere to chemotherapy.Shenqi Fuzheng Injection is mainly made of Codonopsis pilosula and Astragalus membranaceus.It has the functions of benefiting Qi,strengthening spleen and stomach,resisting fatigue,improving immune function of the body,and alleviating the reaction of radiotherapy and chemotherapy.This study observed the effect of Shenqi Fuzheng Injection on CRF of elderly patients with advanced gastrie cancer undergoing chemotherapy.The related scales before and after treatment were compared.The situation of CRF in elderly patients with advanced gastric cancer treated by Shenqi Fuzheng Injection and its influence on quality of life and toxic side effects of chemotherapy were analyzed.It was CRF for elderly patients with gastric cancer undergoing chemotherapy.The treatment provides a new clinical basis.Objective:To study the effect of Shenqi Fuzheng injection on cancer-related fatigue,quality of life and toxicity of chemotherapy in elderly patients with middle and advanced gastric cancer treated with SOX regimen.Methods:60 elderly patients with advanced gastric cancer admitted to Yangzhou Hospital of Traditional Chinese Medicine from July 2015 to December 2018 were randomly divided into observation group(Chemotherapy+Shenqi Fuzheng Injection)and control group(Chemotherapy alone group).The physical strength score,body weight,toxic side effects of quality of life and TCM symptom score of the two groups after two cycles of treatment were compared and analyzed.Result:(1)The effective rate of KPS score in the observation group was higher than that in the control group(P<0.05).(2)Compared before and after treatment,the incidence of moderate and severe fatigue increased and the incidence of mild fatigue decreased after treatment in the observation group,but there was no significant difference in the degree of fatigue before and after treatment in the observation group(P>0.05).Compared with the control group before and after treatment,the incidence of moderate and severe fatigue increased and the incidence of mild fatigue decreased after treatment.The fatigue degree of the control group after treatment was significantly more serious than before treatment,difference was statistically significant(P<0.05).There was no significant difference in fatigue between the observation group and the control group after treatment(P>0.05).The degree of fatigue in the observation group and the control group increased after treatment,but the degree of fatigue in the observation group was less than that in the control group.(3)Compared with the weight change after treatment,the weight stability ratio of the observation group was higher than that of the control group,and the proportion of increase and decrease was lower than that of the control group,but there was no significant difference between the two groups(P>0.05).(4)The QLQ-C30 scale scores before and after treatment were compared.After treatment,the physical function,role function,social function and overall quality of life of the observation group were improved,and the economic difficulties were aggravated(P<0.05).After treatment,the fatigue,nausea and vomiting,loss of appetite and economic difficulties of the control group were aggravated(P<0.05).There was significant difference between the two groups.Compared with the control group,the social function,fatigue,nausea and vomiting,loss of appetite in the observation group were milder after treatment(P<0.05).(5)The toxic and side effects of the two groups were mainly manifested in the digestive system and nervous system of the blood system.The incidence of leucopenia,anemia,thrombocytopenia,nausea and vomiting,anorexia,diarrhea,peripheral neurotoxicity and abnormal liver function in the observation group were lower than those in the control group,and the incidence of leucopenia,nausea and vomiting and anorexia in the observation group was lower than that in the control group(P<0.05).(6)After treatment,the scores of TCM symptoms in the control group were higher than those in the observation group.There was significant difference between the two groups(P<0.01).CONCLUSION:The observation group is superior to the control group in alleviating CRF,improving quality of life and reducing toxicity and side effects of chemotherapy in elderly patients with middle and advanced gastric cancer.It can enhance the patient's tolerance to chemotherapy,improve the quality of life of patients,and provide the possibility for follow-up treatment.However,due to the short observation time,fewer cases,many differences are not significant,the long-term efficacy is not yet certain.The next step can be to further expand the sample size,prolong the treatment time,to further verify the results of this study. |
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