The Clinical Curative Effect Observation Of Shugan Anmian Decoction To Treat Insomnia Of Liver Fire

Objective:To observe the clinical curative effect of modified Shugan Anmiantang treating insomnia of liver fire,and evaluate its safety.Methods: The 70 patients who met the inclusion criteria were randomly divided into experimental group and control group,each group had 35 patients.The treatment of experimental group was:danpi 12 g,chaozhizi 10 g,chaihu 12 g,chaobaizhu 15 g,baishao15g,danggui 12 g,fuling 30 g,xiangfu 10 g,shenglonggu 30 g,hehuanpi 20 g,hehuanhua30g.meigihua 15 g,Drinking a dose of medicine everyday,blunt with 200 ml of water,and divided into morning and evening two times.The treatment of control group was:Danzhixiaoyao tablet,5 tablets,bid.During the treatment,it is forbidden to take sleeping pills,prohibiting the use of all non drug therapy to treat insomnia.Patients who combine of other diseases and must take medicine,the medicine must be marked in the personal data.The duration of treatment was 4 weeks,the data from Pittsburgh sleep quality index(PSQI)and Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)and symptomatic score chart of Chinese medicine of two groups were processed with SPSS19.0 to see the difference after the treatment.The patient’s discomfort was recorded in the treatment,and compare each groups,difference of blood routine,liver function,renal function,and electrocardiogram after treatment,evaluate the safety of drugs objectively.Results:1.Efficacy evaluation: 7 cases in the experimental group were cured,markedly effective is 13 cases,effective is 12 cases,ineffective is 2 cases,the total effective rate is91.18%.4 cases in the control group was cured,markedly effective is 9 cases,effective is 12 cases,ineffective is 9 cases,the total effective rate is 78.79%.After treatment,the difference between the two groups was statistically significant(P<0.05).2.Pittsburgh sleep quality index(PSQI)scale comparison:After treatment compared with before treatment,two groups have statistically significant difference(P<0.05),and the difference between the two groups after treatment have statistically significant difference(P<0.05).3.Comparison of TCM symptom score:After treatment compared with before treatment,two groups have statistically significant difference(P<0.05),and the difference between the two groups after treatment have statistically significant difference(P<0.05).4.Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)comparison:After treatment compared with before treatment,two groups have statistic ally significant difference(P<0.05),and the difference between the two groups after tr eatment have statistically significant difference(P<0.05).5.Safety evaluation: During the course of medication,2 patients in the experimental group showed mild discomfort,and continued to take the medication.Blood routine,liver function,renal function,and electrocardiogram of two groups before and after treatment had no statistically significant difference(P>0.05).Conclusion:Modified Shugan Anmiantang and Shumian capsules both are safe and effective.Modified Shugan Anmiantang can significantly improve sleep quality and symptoms of patients,is worthy of further study and clinical use.