Observation On The Efficacy Of Jinfeng Pill In The Prevention And Treatment Of Re-Adhesion After Intrauterine Adhesions

Background and objectiveIntrauterine adhesions are one of the most common gynecological benign diseases that seriously affect women’s fertility,and the incidence rate is increasing year by year and younger.With the popularization and development of hysteroscopic techniques,the diagnosis rate of intrauterine adhesions is significantly improved.Hysteroscopy can understand the nature,extent and clinical stage of intrauterine adhesions under direct vision,and in the invasive environment,the uterine adhesions were separated by balloon dilatation,blunt dissection and electrotomy to reconstruct the normal anatomical structure of the uterine cavity.However,because the anatomical structure of the endometrium is different from other mucosal tissues,the recovery after damage is more difficult and involves multiple links.Therefore,the uterine adhesions have been improved over the years by continuously improving the surgical technique and improving the postoperative prevention of adhesion.The cure rate of the disease,but its effect is still not satisfactory.At present,the most common drug for preventing re-adhesion after intrauterine adhesions is estrogen.Estrogen promotes endometrial growth by binding to its receptor,covering the damaged tissue to achieve anti-adhesion,but if there is no residual in the uterine cavity.Membrane tissue,estrogen receptor deficiency,endometrial dysfunction,estrogen alone can not promote endometrial growth,even if there is residual endometrium and its receptor in the uterine cavity,if there is a lack of good blood supply in the uterine cavity,The therapeutic drug cannot be transported to the endometrium to function locally,and is also detrimental to the growth of the endometrium.Therefore,the use of estrogen alone to prevent the occurrence of re-adhesion after intrauterine adhesions is not satisfactory.In recent years,the rapid development of traditional Chinese medicine in the treatment of intrauterine adhesions has gradually attracted the attention of clinicians.The combination of traditional Chinese and western medicine has gradually become a new trend in the prevention of re-adhesion after intrauterine adhesions.This study was to analyze the clinical efficacy of Jinfeng Pill combined with traditional medicine Bujiale in the treatment of anti-adhesion after hysteroscopic intrauterine adhesions,in order to explore the effect of Jinfeng Pill on reducing the re-adhesion of postoperative patients.Methods and SubjectsFrom November 2016 to October 2017,hysteroscopy was performed in the gynecological department of the Second Affiliated Hospital of Zhengzhou University.68 cases of intrauterine adhesions were diagnosed by hysteroscopic examination.Hysteroscopic intrauterine adhesions were performed.68 patients with intrauterine adhesions underwent hysteroscopic intrauterine adhesions were randomly divided into B group and 32 patients were given A group,18 cases of moderate adhesion,severe adhesion 18.Jinfeng Pill + Progynova drugs were orally administered,and 36 patients in the B group,17 cases of moderate adhesion,severe adhesion 15,were given oral supplemental drugs only for 3 cycles.The two groups of patients measured the maximum blood flow velocity of the endometrium,PI,RI and endometrial thickness,recorded postoperative menstrual improvement and hysteroscopy Check the situation and compare the two sets of data.Statistical analysis was performed using SPSS 21.0 software.The measurement data were expressed as mean±standard deviation().The t-test was used.The count data was expressed as a percentage.The chi-square test was used.The degree of intrauterine adhesion was compared by rank sum test.Level α = 0.05.Results1.In the B group,total improvement rate of menstruation 93.8% was obviously higher than that in the A group 66.7%(P=0.022).2.The thickness of endometrial growth 7.2431±1.04387 in the B group was significantly higher than that in the A group after treatment.The thickness of the endometrium was 6.4619±0.85610,and the difference was statistically obvious(P=0.001).3.In the B group,total effective rate of uterine cavity recovery after treatment 93.8% was obviously higher than that of the A group 66.7%(P=0.022).4.The maximal blood flow velocity of the left and right endometrium 38.519±0.6038,38.591±0.3905 in the B group was significantly higher than that in the A group 35.286±0.8509,35.264±0.8292(P=0.000、P=0.000),and the left and right uterine artery pulsatility index 2.8722±0.14524,2.8813±0.15937,uterine artery blood flow resistance index 0.7803±0.09021,0.7756±0.09112 was significantly lower than the A group 3.0031±0.15175,3.0031±0.13541(P=0.001、P=0.001,0.8236±0.08702,0.8203±0.08807(P=0.048、P=0.044),the difference was statistically significant.Conclusions1.Jinfeng Pill combined with estrogen can significantly improve the amount of menstruation after intrauterine adhesions.2.Jinfeng Pill combined with estrogen can significantly promote the growth of endometrium after intrauterine adhesions,and help prevent postoperative adhesions.3.Jinfeng Pill combined with estrogen can significantly increase endometrial blood supply,which is beneficial to increase the utilization rate of therapeutic drugs such as estrogen,promote endometrial growth,and reduce postoperative re-viscosity.