Analysis Of Bone Metabolism Related Factors In Type 2 Diabetes Mellitus

Objective: To investigate the factors affecting bone metabolism in type 2diabetes mellitus.Methods: A total of 177 patients with T2 DM admitted to the department of endocrinology and metabolism of guangxi zhuang autonomous region people’s hospital from January 2015 to December 2018 were retrospectively selected,including 45 male patients.132 female patients were divided into female osteoporosis group and female low bone mass group according to the bone density T value.According to the presence or absence of vascular lesions,the patients were divided into T2 DM group with vascular lesions and T2 DM group without vascular lesions.Collection records research object general clinical data,the change of biochemical index and bone biochemical indexes,determined by dual energy X-ray absorptiometry(dexa)on the left side of the hip(femoral neck,femoral rotor,ward ’ s),lumbar spine bone mineral density(BMD at L1-L4),parallel head CT or MRI,electrocardiogram,echocardiography and coronary CTA or coronary angiography,blood vessels,colour to exceed,limb doppler blood flow diagram,fundus photography and related inspection.SPSS23.0 statistical software was used for statistical analysis,and P < 0.05 indicated that the difference was statistically significant.Results:(1)In the male group,there were statistically significant differences in body weight and BMI between the osteoporosis group and the low bone mass group(P < 0.05).Correlation analysis showed that bone formation index P1 NP was positively correlated with PTH(r=0.323,P < 0.05),and was positively correlated with β-CTX(r=0.526,P < 0.01).Bone resorption indexβ-CTX was negatively correlated with BMI(r=-0.418,P < 0.01).There was a significant positive correlation with P1NP(r=0.526,P < 0.01).(2)In the female group,the comparison of HbA1 C,P1NP,β-CTX between the osteoporosis group and the low bone mass group was statistically significant(P < 0.05,P < 0.01).Bone conversion indexes P1 NP and β-CTX were significantly higher in the osteoporosis group than in the low-bone group,and the comparison between the two groups was statistically significant(P=0.001,P=0.006).Meanwhile,the prevalence of diabetic retinopathy in the female osteoporosis group was significantly higher than that in the low bone mass group,and the difference was statistically significant(P < 0.05).Bone conversion index P1 NP was positively correlated with cIMT,and the difference was statistically significant(r=0.170,P < 0.05).There was a positive correlation between β-CTX and UAE(r=0.219,P < 0.05).There was a negative correlation with Ccr and the difference was statistically significant(r=-0.195,P < 0.05).(3)Binomial Logistic regression analysis showed that retinopathy was closely related to bone mineral density in the female group and was the main factor affecting bone mineral density(OR=0.443,P < 0.05).Conclusion :(1)Compared with the low bone mass group,the bone formation and bone resorption of type 2 diabetic patients with osteoporosis were significantly increased.(2)Among patients with type 2 diabetes,BMI,HbA1 c and PTH were correlated with bone density.(3)Retinopathy in postmenopausalwomen with type 2 diabetes may be an important factor affecting bone mass.