Task-related Of Go/No-go Task With Band Asymmetry In Major Depressive Disorder:a MEG Study

Objective:Cognitive impairment is the most significant symptom of all clinical symptoms in diagnosis of major depressive disorder(MDD)patients.The main neuropsychological and cognitive symptoms of depression were executive dysfunction.Alpha power can reflect top-down inhibition control executive processes.In this study,task-related alpha power were respectively extracted from the MDD group and the healthy control group.There is a significant difference between the alpha power and alpha-asymmetry power of brain regions that may be involved in cognitive impairment in MDD group.Thus,the alpha power asymmetry can be used as an objective clinical marker in neuroimaging to aid in the diagnosis of MDD.Methods:A total of 41 participants from the Nanjing Brain Hospital affiliated of Nanjing Medical University were enrolled in the outpatient and inpatients,including 24 patients with depression and 17 healthy controls.The Go/No-go task brain magnetic signal and the resting state functional magnetic data were collected.The data processing and analysis methods are as follows:The 275-channel full-head magnetoencephalography CTF system was used to collect the brain magnetic signals under Go/No-go task,and the bilateral frontal superior gyrus,bilateral frontal middle gyrus,bilateral frontal superior medial gyrus,bilateral cingulum anterior gyrus,bilateral parietal superior gyrus,bilateral parietal inferior gyrus,bilateral supramarginal gyrus,bilateral angular gyrus were selected as the brain regions of interest.The time periods of 0-300ms,300-600ms,and 600-900ms after stimulation are selected respectively.Calculate the energy of each brain region of interest,and obtain the energy values of the brain regions of interest in the alpha band at different time periods.The follow-up study will be divided into the following steps:(1)Comparison of significant brain regions with power values in the alpha bandThe alpha power values of the brain regions of interest in the depression group and the healthy control group were compared using the replacement test for the Go/No-go task.(2)Comparison of significant brain regions with the alpha asymmetry power valueAfter the alpha asymmetry power values of the brain regions of the depression group and the healthy control group were separately treated,the displacement test was used to compare the two groups of alpha band lateralization values under the Go/No-go task.(3)Spearman correlation analysis between the asymmetry of significant brain regions with the alpha asymmetry power value and the Wisconsin card sorting testFirst,the alpha asymmetry power values of the regions of significant interests in depression group are extracted.Then,the item results of the Wisconsin card sorting test from 19 patients are using spearman correlation to analysis the correlation between asymmetry alpha power and Wisconsin card sorting test items.Results:(1)Comparison of significant brain regions with power values in the alpha bandUsing permutation test to compare between MDD group and healthy control group,in aim of the alpha power value in the regions of interest with Go/No-go task.The results showed that there are significant differences alpha power values in Go condition in period of 600-900ms between the left frontal superior gyrus(P=0.007)and the left frontal superior gyrus(P=0.01).In No-go conditions,there are significant differences alpha power values in period of 600-900ms between the right frontal middle gyrus(P=0.001).(2)Comparison of significant brain regions with the alpha asymmetry power valueUsing permutation test to compare between MDD group and healthy control group,in aim of the alpha asymmetry power value in the regions of interest with Go/No-go task.The results showed that there are significant differences alpha asymmetry power values in Go condition after using Bonferroni correction in period of 0-300ms in the frontal middle gyrus(P=0.005)and 300-600ms in the frontal superior medial gyrus(P=0.002).In No-go conditions,there are significant differences alpha asymmetry power values after using Bonferroni correction in period of 300-600ms(P=0.000)and 600-900ms(P=0.000)the cingulum anterior gyrus and in period of 0-300ms in the parietal inferior gyrus(P=0.000).(3)Spearman correlation analysis between the asymmetry of significant brain regions with the alpha asymmetry power value and the Wisconsin card sorting testThe Spearman correlation analysis was used to analyze the correlation between the asymmetry of the alpha power in regions of significant of interests and the Wisconsin card sorting test items.The results show that there have a low to moderate correlation between the asymmetry alpha power of 600-900ms in the cingulum anterior gyrus after No-go stimulation and three Wisconsin card sorting test items.The items "Trials Administered"(rs=-0.510,P=0.026)and "Nonperseverative errors",(rs=-0.477,P=0.039)are negatively correlated with "600-900ms after No-go stimulus in thecingulum anterior gyrus".The item "Conceptual Level Responses"(rs=0.512,P=0.025)is postively correlated with "600-900ms after No-go stimulus in the cingulum anterior gyrus",which correlation is also the most relevant.Conclusion:The Go/No-go task reflected good motor response,exercise preparation and inhibition.The alpha power in Go/No-go task showed that in the left frontal superior gyrus,the left frontal superior gyrus,and the right frontal middle gyrus was significantly different between depression group and healthy control group.The alpha asymmetry power in Go/No-go task showed that the frontal middle gyrus,the frontal superior medial gyrus,the cingulum anterior gyrus,the parietal inferior gyrus was significantly different between depression group and healthy control group.The significant correlation between alpha asymmetric brain regions and sub-item scores of Wisconsin card sorting test was consistent at the later stage of the cingulum anterior gyrus stimulation,indicating that cognitive inhibition was effectively reflected in the cingulum anterior gyrus in the depression group.Particularly,conflict monitoring and attention control are strongly reflect executive dysfunction.In the end,these results show that there are significant differences in alpha power and alpha power asymmetry between the patients and the healthy controls,and the conclusion can be that the impairment of cognitive inhibition could be used in analyzing the functional properties of brain regions and the alpha power changes.