| Objective: To explore the influencing factors of family aggregation of hepatitis B infection in minority areas of Guizhou Province and to analyze the influence of family structure and knowledge of hepatitis B among residents on family aggregation,so as to provide scientific basis for prevention and control of hepatitis B.Methods: A total of 924 permanent residents of 411 families were randomly selected by multistage cluster random sampling in minority areas of Guizhou province in 2013 and collected 5m L venous blood to test HBV serological index.Using two-level binary logistic regression model and single-level binary unconditional logistic regression model to analyze the influencing factors of family aggregation of hepatitis B infection.Two-class unconditional logistic regression model was used to analyze the influence of family structure and knowledge of hepatitis B among residents on family aggregation.OR(95%CI)was calculated to evaluate the relationship between different influencing factors and family aggregation of hepatitis B infection.Results: With family population level 2 and individual level 1,the zero model has statistical significance(P < 0.05).Two-level binary logistic regression analysis showed that smoking(OR=1.837,95%CI:1.057-2.917)and living with HBs Ag positive people were risk factors for family clustering of hepatitis B infection;students(OR=0.140,95%CI:0.025-0.797),condom use during sexual intercourse between husband and wife(OR=0.438,95%CI:0.207-0.927)and inoculated with hepatitis B vaccine(OR=0.281,95%CI:0.092~0.863)were protective factors(P < 0.05).The highest clustering rate of hepatitis B infection was found in three generations of cohabitant families(56.8%)and the highest rate of hepatitis B infection was found in families with different generations(57.7%).There was significant difference in family aggregation among families with different family structures(χ 2 =38.983,P<0.01).With traditional families as the control group,bi-categorized unconditional Logistic regression analysis showed that the risk factors of family aggregation were atavism families(OR= 2.544,95% CI:1.254-5.160),three-generation cohabitant families(OR = 3.984,95% CI: 2.497-6.357).The family knowledge score of hepatitis B was lower(0-13 points)as the control group,14-16 points(OR = 0.278,95%CI: 0.168-0.459),17-22points(OR=0.253,95%CI: 0.159-0.403)as the protective factors of family aggregation of hepatitis B infection(P <0.05).Residents with better knowledge of hepatitis B had lower rate of hepatitis B infection(40.9%)and lower rate of family aggregation(31.3%)with higher score of family knowledge of hepatitis B.Three core knowledge points affecting hepatitis B infection: what are the main measures to prevent hepatitis B infection(OR= 0.726,95% CI: 0.543-0.973,P< 0.05),whether condom use can prevent hepatitis B sexually transmitted(OR = 0.496,95% CI: 0.332-0.741,P< 0.05),and whether hepatitis B can be transmitted(OR = 0.693,95% CI: 0.486-0.988,P< 0.05).Multilevel model is more suitable for the analysis of influencing factors of family aggregation.Family structure and knowledge of hepatitis B affect family aggregation.Conclusion: We should publicize healthy lifestyle,vaccinate residents with hepatitis B infection in their homes,make regular hepatitis B examination,strengthen the health education for the prevention of hepatitis B among atavism families,enhance the awareness of self-prevention and health care,strengthen the publicity and education of hepatitis B knowledge,especially in the aspects of hepatitis B vaccination and hepatitis B sexually transmitted,and improve the accessibility of hepatitis B vaccination services in economically backward areas. |
