A Retrospective Study Of Family Clusters Of Hepatitis B And Cirrhosis

Purpose:To investigate whether there is any difference in the distribution of TCM syndromes and related indicators between patients with family history and no family history of Hepatitis B liver cirrhosis(HBC),and scientifically provide a theoretical reference for early treatment of hepatitis B cirrhosis.Method:A retrospective analysis approach was used.194 cases of hepatitis B cirrhosis that met the inclusion criteria in the liver disease clinic of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were collected,including 108 cases with family history and 86 cases without family history.The general situation and family history of the two groups were retrospectively analyzed.Child-Pugh liver function classification,TCM syndrome type,and blood biochemical indicators were statistically analyzed using SPSS20.0statistical software.Results:1.Among the HBC patients with family history,69 males and 39 females;in all ages,41-60 years old patients,the average age of onset(50.51±10.286)years;Child-Pugh liver function A grade 38 cases There were 58 cases of grade B and 12 cases of grade C.There were 14 cases of syndrome of liver-qi stagnation in TCM syndrome type,18 cases of water-wet internal suspension syndrome,15 cases of damp-heat accumulation syndrome,9 cases of blood stasis syndrome,and liver-kidney yin deficiency syndrome.22 cases,30 cases of spleen and kidney yang deficiency syndrome,spleen and kidney yang deficiency syndrome > liver and kidney yin deficiency syndrome > water and wet cessation syndrome > damp heat accumulation syndrome > liver qi stagnation syndrome > phlegm blood stasis syndrome(p <0.05).2.Among the family history patients,there were at least one HBC patient with hepatitis B in the immediate family 28 syndrome types: spleen and kidney yang deficiency syndrome >liver and kidney yin deficiency syndrome > damp heat accumulation syndrome > liver qi stagnation syndrome,blood stasis Circulation > Water-wet internal arrest syndrome p<0.05);47 cases of HBC patients with at least one hepatitis B cirrhosis in immediate family members,syndrome classification: water-wet internal suspension syndrome> spleen-kidney yangdeficiency syndrome> liver-qi stagnation syndrome> liver and kidney Yin deficiency syndrome> phlegm blood stasis syndrome p<0.05);24 cases of HBC patients with at least one liver cancer in immediate family members,syndrome classification: spleen and kidney yang deficiency syndrome > liver and kidney yin deficiency syndrome > liver qi stagnation syndrome > damp heat accumulation Syndrome,phlegm and blood stasis syndrome >water-wet internal arrest syndrome p<0.05);and only 9 cases of HBC patients with family-related non-immediate relatives suffering from hepatitis B-related diseases,syndrome classification: water-wet internal suspension syndrome,damp heat accumulation Card> liver and kidney yin deficiency syndrome(p<0.05).3.Among the HBC patients without family history,there were 60 males and 26 females;most of them were 51-70 years old,with an average age of onset(60.07±8.529)years old,and Child-Pugh liver function A grade 65 cases,grade B.18 cases,3 cases of C grade(p<0.05);38 cases of liver-qi stagnation syndrome distributed in TCM syndrome type,6 cases of water-wet internal stop syndrome,9 cases of damp-heat accumulation syndrome,22 cases of blood stasis syndrome,liver and kidney yin deficiency 5 cases of syndrome,6 cases of spleen and kidney yang deficiency syndrome,liver qi stagnation syndrome> phlegm and blood stasis syndrome> damp heat accumulation syndrome> spleen and kidney yang deficiency syndrome> water and wet internal cessation syndrome> liver and kidney yin deficiency syndrome(p<0.05).Conclusion:1.In this study,HBC patients with family history and no family history were more male than female,but family history of HBC patients had a younger onset.2.The HBC patients with family history had a grade B of liver function at the time of treatment.The blood biochemical indicators reflected the severity of the disease,suggesting poor liver function reserve.3.The HBC patients with family history of TCM syndrome type are mostly spleen and kidney yang deficiency syndrome and liver and kidney yin deficiency syndrome.HBC patients without family history are mostly liver qi stagnation syndrome and blood stasis syndrome.