| Objective In this study,the prevalence of dyslipidemia in the surveyed population was obtained through investigating the elderly over 60 years old in Lu’an City.The whole body’s whole blood heavy metal elements were tested to explore the risk of polymetallic exposure and dyslipidemia in old population.The association of the risk of dyslipidemia provides early prevention strategies and measures for the prevention and treatment of dyslipidemia in the elderly.Methods In total,1013 participants aged≥60 years using cluster sampling method from two communities of Lu’an City were enrolled in this community-based study from June to September 2016.A self-made questionnaire was used to collected the information of demographic characteristics,lifestyles,ect.The face-to-face survey was conducted by the unified training investigators.Whole blood heavy metals concentration were measured by inductively coupled plasma mass spectrometer(ICP-MS)and evaluate metals exposure were evaluated.Chi-square test(?~2)and t test were used to analyze the differences of basic population.Mann-Whitney U test was used to analyze the difference of whole blood heavy metal concentration in different groups.Binary logistic regression was used to explore the association between whole heavy blood metal level and the risk of dyslipidemia.Pearson correlation analysis was used to analyze the correlation between metals.Finally,principal component analysis was used to explore the relationship between polymetallic combined exposure and dyslipidemia.Results A total of 1080 people were investigated in this study.The final inclusion of1013 elderly,461 males and 552 females.Participants with a history of hypertension,diabetes and cardiovascular disease accounts(including coronary heart disease and stroke)for 71.6%,23.6%and 7.2%of the total population,respectively.The number of participants with dyslipidemia was 533(52.6%).The prevalence of hypertriglyceridemia(HTG),hypercholesterolemia(HTC),high low density lipoprotein cholesterol(LDL-C),and low high density lipoprotein cholesterol(HDL-C)were 19.3%,38.8%,15.1%and1.2%,respectively.The average age of the subjects was 71.6±6.4 years.The?x±s of body mass index(BMI)was 24.17±3.72 kg/m~2.The levels of strontium(Sr)and lead(Pb)in the whole blood of dyslipidemia group were significantly higher than those of the normal group(P<0.05).The binary logistic regression analysis showed that after adjusting the population distribution characteristics,subjects in the highest lead quartile group had 2.13 times higher risk for dyslipidemia than those in the lowest quartile group.Subjects in the highest Pb quartile group had 2.16 times the risk for HTG compared with those in the lowest quartile group.Compared with the first quintile,the odds ratio(OR)for HTC of blood Sr and Pb in the highest quintile were 2.08(95%CI:1.36,3.16)and2.61(95%CI:1.68,4.04),respectively.Compared with the first quintile,the odds ratio(OR)for for high density lipoprotein cholesterol of blood manganese(Mn),Pb and aluminium(Al)in the highest quintile were 2.42(95%CI:1.41,4.14),2.37(95%CI:1.34,4.17)and 1.85(95%CI:1.10,3.12),respectively.Although Mn is a risk factor for low HDL-C in the elderly,there is no statistically significant difference in the risk of dyslipidemia between the subjects with different Mn level groups.These associations were still statistically significant after further adjustments in lifestyle and chronic disease.There was a significant correlation between the metal elements of whole blood(P<0.05).It was found that the combined exposure to Al,Co and V is a protective factor and combined exposure to cadmium(Cd),Sr and Pb is a risk factor for dyslipidemia after principal component analysis.Conclusions This study found that exposure to heavy metal levels in whole blood may increase the risk of dyslipidemia.There are correlations among various heavy metals and multiple metal exposures may increase the risk of dyslipidemia.This study provides a data base for heavy metal exposure and health in the elderly population,and the results need to be confirmed by further research. |
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