| Objective: To summarize the clinical features of general examination in PET/CT center of Anhui Provincial Hospital by retrospective study Imaging and in-patient clinical data of patients with Diffuse large B cell lymphoma(DLBCL);To explore the correlation between DLBCL's pathological characteristics,overall treatment and the curative effect and prognosis after treatment,so as to explore the application value of PET/CT in DLBCL,provide theoretical reference for judging the prognosis of DLBCL,and further standardize the clinical individualized treatment,thus providing an effective basis for promoting the standardized diagnosis and treatment of DLBCL in our hospital.MethodS: 64 cases of DLBCL patients admitted by Anhui Provincial Hospital from January 1,2010 to December 31,2016 who were confirmed by histopathology after surgery or biopsy were collected as subjects.Firstly,understand the pathological characteristics of DLBCL patients,the overall treatment situation and the therapeutic effect distribution after treatment;Secondly,general conditions of DLBCL patients were analyzed: age,gender,hepatitis b virus infection;Clinical characteristics: first symptoms,first site,IPI(International Prognostic Index)score,clinical stage,bone marrow invasion.Pathological characteristics: pathological type,source of tumor cells and cell proliferation index(ki-67);Treatment status: treatment,different treatment regimens,different chemotherapy regimens and short-term efficacy of initial treatment(complete remission rate);18F-FDG PET/CT imaging results of 42 patients with diffuse large B-cell lymphoma were obtained from the PET/CT machine in our hospital.All patients were divided into germinal center type(GCB type)and non-GCB type(non-GCB type)according to the classic Hans classification.Then,the correlationbetween SUV Max obtained after examination of each patient and its corresponding Ki-67 value was studied,and the two groups of Ki-67 with different immune classification were compared.Results: General conditions: among the 64 cases of DLBCL patients,female patients were slightly more than male patients(male: female =1.207).The median age was 59,accounting for 53.13%(34/64).Among the 64 patients,patients infected with HBV(HBs-Ag positive)accounted for 26.56%(17/64),and 4 patients with HCV&HBs-Ab accounted for 6.25%.Clinical features: 45 patients(45/64,70.31%)had primary lymph node involvement,while the first symptom was superficial lymph node enlargement(or mass),up to 64.01%(41/61).Among the 19 patients(19/64,29.69%),the gastrointestinal tract accounted for the most(10/64,16%).In the IPI prognosis group,the scores of 0-2 and 3-5 were 56.76%(21/37)and 43.24%(16/37)respectively.Clinical staging ?-? accounted for 43.64%(24/56),III-IV accounted for 56.36%(31/56);Among the 64 patients with DLBCL,PET imaging indicated liver,spleen and bone marrow infiltration in 15 cases(15/64,23.43%).A total of 46 patients were able to measure the diameter of the lesion,in which 7.5cm was used as the demarcation point of the large mass,and <7.5cm was significantly more than 7.5cm(39/46,84.78% vs7/46,15.22%).Four cases(8.70%,4/46)were diagnosed as large masses with a diameter of10.0cm or greater.Pathological features: among the 64 cases of DLBCL,10 cases had unclear immune typing.Among the 54 cases with known immune types,non-GCB was the most common,with 43 cases accounting for 79.63%(43/54),while GCB type only accounted for 11 cases(20.37%(11/54).In the 60 patients,Ki-67 was detected,and >50% expression was dominant(53/60,88.33%),among which 32 patients with > 50 and< 75(53.33%(32/60),and 21 patients with greater than 75(35%).Treatment: in 64 patients with DLBCL,52 patients treated in our hospital,among them 35 cases(54.69%)with R-CHOP plan as a line,and 10 cases(15.63%)patients preferred CHOP plan,other chemotherapy regimens in 7 cases(10.94%),after the first treatment and curative effect assessment of 37 patients with DLBCL,21 cases of clinical CR,33 patients without CR(PR15 cases,9 cases of PD and recurrence),complete remission rate was56.74%.2.For 64 patients with DLBCL,the median of SUV Max was.Will be non-type GCB and GCB for SUVmax,an independent sample t-test,Max and SUV Max correlation analysis with corresponding Ki-67,tip: patients with DLBCL lesions 18 F-FDG SUV Max and Ki-67 level was significantly positive correlation between,correlation coefficient r of 0.153,GCB type and non-GCB type of DLBCL SUV,an independent sample t-test,Max results have no significant difference,P were greater than 0.05(P value are 0.0923 and 0.801).Conclusion: 1.The results showed that there was no significant difference between SUV of GCB and non-GCB DLBCL,which was consistent with previous reports.The possible reasons were as follows: 1.2.Since DLBCL is a kind of systemic tumor disease(including some primary bone marrow and later bone marrow infiltration),its pathological biopsy part is not completely consistent with the part where the maximum value of SUV obtained by PET/CT,resulting in partial bias.3.The SUV Max of the lesion may not reflect the invasiveness of the tumor,and the average SUV may be more representative.4.This study is limited to a certain region,and the sample size is not enough.Therefore,a large sample with multiple centers is required. |
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