Antiallergic Compounds From The Deep-sea-derived Aspergillus Nidulans And Penicillium Griseofulvum

Food allergy is one of the commonly found allergic disease among human beings.With the incidence increasing every year,it seriously affects the health of people.However,current clinically available medicines cannot work effectively.Therefore,27 deep-sea-derived fungi were selected for chemical and anti-allergic investigation.As a result,two strains of Aspergillus nidulans and Penicillium griseofulvum were targeted for systematic chemical constituent study because of their diverse components and significant bioactivity.From Aspergillus nidulans,19 compounds were obtained,including four anthraquinones(1–4),13 steroids(5–17),one phenolic(18),and one polyketide(19).While a total of 49 compounds were isolated and identified from Penicillium griseofulvum,consisting of nine terpenoids(20–28),19 alkaloids(29–47),three peptides(48–50),and 18 miscellaneous compounds(51–68).All 68 isolates were tested for in vitro anti-allergic activity.Compounds 1,25,28,33,and 42 showed significant effect(IC50 ? 97.3 ?M)compared to that of the positive control,loratadine(IC50 = 91.6 ?M).Noteworthily,compound 1(IC50 = 1.8 ?M)showed 50-fold stronger effect than loratadine,indicating its potential as an anti-allergic lead compound.