Clinical Research On Intervention Of COPD Patient In The Stable Stage With Lung-kidney Qi Deficiency?Phlegm-blood Stasis Obstructiong Lung Syndrome Based On The Principle Of "Take Measures Suited To The Times"

[Objective]To preliminarily explore the clinical efficacy of combined treatment at different times of traditional Chinese medicine under the guidance of the principle of"take measures suited to the times"in treating patients with COPD in stable phase?lung-kidney Qi deficiency,phlegm-blood stasis obstructing lung syndrome?.[Methods]This study was a randomized controlled clinical study.Patients with COPD in stable phase?lung-kidney Qi deficiency,phlegm-blood stasis obstructing lung syndrome?were selected as subjects.The cases originated from the respiratory outpatient department of the First Affiliated Hospital of Anhui University of Chinese Medicine,the Sanli'an Street Community and the Xiyuan Street Community Healthcare Service Center of Hefei City.A total of 61 patients were collected and divided into observation group?31 cases?and control group?30 cases?according to random number table method.During the study period,2 cases were excluded from the observation group,and 59 cases were included in the final statistical analysis.The control group was treated with Seretide on the basis of traditional western medicine,while the observation group was treated with combined treatment at different times of traditional Chinese medicine?summer solstice acupoint application therapy,autumnal equinox Chinese medicine iontophoresis and winter solstice Chinese medicine oral?on the basis of the control group,the course of treatment was about 8 months in both groups.The changes of FEV₁%pred,the score of syndromes in Chinese medicine,CAT score,the number and degree of acute exacerbation annually were compared before and after treatment.The data were analyzed by SPSS21.0 statistical software.[Results]1.There were no significant differences in baseline data,FEV₁%pred,the total score of syndromes in Chinese medicine,scores of individual symptoms,CAT scores,the number of annual acute exacerbation between the two groups before treatment?P>0.05?.2.Comparison of pulmonary function:There was no significant difference in FEV1%pred between the two groups before and after treatment?P>0.05?;there was no significant difference in FEV₁%pred between the two groups after treatment?P>0.05?,but the average FEV₁%pred in the observation group increased after treatment,while the average FEV1%pred in the control group decreased after treatment.3.Comparison of the score of syndromes in Chinese medicine:?1?The total score of syndromes in Chinese medicine:After treatment,the total score of syndromes in Chinese medicine of the two groups were significantly lower than those before treatment?P<0.01?;after treatment,the total score of syndromes in Chinese medicine of the observation group were significantly lower than those of the control group?P<0.05?.?2?The scores of individual symptoms:After treatment,the other symptoms in the observation group were significantly improved except for tongue manifestation compared with those before treatment?P<0.05 or P<0.01?.the symptoms of cough,expectoration,wheezing,cold and chest tightness in the control group were improved?P<0.05 or P<0.01?,while the symptoms of shortness of breath,tongue quality,soreness of waist,frequency of urine and edema were not significantly improved?P>0.05?.After treatment,the observation group was superior to the control group in improving the symptoms of expectoration,shortness of breath,cold,lumbar acid,frequency of urination and edema?P<0.05 or P<0.01?.4.Comparison of the CAT scores:After treatment,the CAT scores of the two groups were significantly different from those before treatment?P<0.01?;after treatment,the CAT scores of the observation group were significantly lower than those of the control group?P<0.01?.5.Comparison of the number and severity of annual acute exacerbation:The number and severity of acute aggravation in one year of treatment in both groups was lower than that in one year before treatment?P<0.01?;there was no significant difference in the number of acute aggravation in one year between the two groups?P>0.05?,but the severity of acute aggravation in the observation group was significantly lower than that in the control group?P<0.01?.[Conclusion]The time-sharing comprehensive scheme of TCM based on the principle of"take measures suited to the times"has a definite clinical effect on COPD patients in stable stage?lung-kidney Qi deficiency,phlegm-blood stasis obstructing lung syndrome?.It can delay the decline of pulmonary function,alleviate clinical symptoms,reduce the frequency and severity of acute attacks,and improve the quality of life.