Clinical Study Of Tongqiao Dingxuan Decoction Combined With Betahistine In The Treatment Of Posterior Circulation Ischemic Vertigo(Syndrome Of Phlegm And Blood Stasis OBstructing OrIfices)??

Objective:Standardized clinical trials of patients with posterior circulation ischemic vertigo(syndrome of phlegm and blood stasis obstructing orifices)were treated with Tongqiao Dingxuan Decoction combined with betahistine,by recording the TCM syndrome scores before and after treatment,the European vertigo scale(EEV)score,the stunner scale(DHI-S)score,and blood flow values detected by Trananial Cerebral Dpooler(TCD)and plasma viscosity values to evaluate the clinical effectiveness and safety of the method,and to provide data support for the instructor's clinical experience.Method:According to the principle of randomized control,64 patients who met the inclusion criteria were divided into control group and treatment group,32 cases each.The control group received betahistine mesylate tablets(6mg/time,three times/day).The treatment group was given Tongqiao Dingxuan Decoction(water decoction 150 ml,daily dose,morning and evening)on the basis of the control group.2 weeks.On the first day of treatment and the 14 th day of treatment,TCM syndrome scores,EEV scores and DHI-S scores,blood flow values of TCD,plasma viscosity and blood routine,liver and kidney function,and ECG were recorded.Observe the patient's condition changes and adverse drug reactions during treatment.Finally,2 patients in the treatment group were excluded from the rejection test,and 2 patients in the control group were excluded due to irregular medication.A total of 60 patients completed clinical observation,including 30 in the treatment group and the control group.Results:1.Baseline indicator comparison:Statistical analysis showed that there were no significant differences in gender,age,duration of disease,degree of dizziness,risk factors of cerebrovascular disease and differences between the two groups before treatment(P>0.05),which were comparable.2.The total effective rate of the two groups was compared: the two groups were effective in the treatment of posterior circulation ischemic vertigo(syndrome of phlegm and blood stasis obstructing orifices).The clinical effective rate was 90% in the treatment group and 73.3% in the control group,the difference was statistically significant(P <0.05).3.Comparison of TCM syndrome scores between the two groups: Both groups of drugs can improve the patient's dizziness,nausea and vomiting,fatigue,head discomfort,frequency of onset,etc.,tatistically significant(P<0.05),but both groups of drugs are The scores of tinnitus and deafness symptoms could not be effectively improved,and there was no statistical difference(P>0.05).After treatment,the treatment group was better than the control group in terms of dizziness,fatigue,fatigue,head confusion,and seizure frequency(P<0.05).4.Comparison of EEV scale scores and DHI-S scores between the two groups: The EEV scores and DHI-S scores of the two groups were significantly lower than those before treatment(P<0.01),and there was a statistically significant difference.The EEV score and DHI-S score of the treatment group were compared between the two groups.Compared with the control group,the decrease was significant(P<0.01),indicating that the treatment group was more effective.5.Comparison of Vs,Vm and PI between vertebral artery and basilar artery in two groups:The Vs and Vm of VA and BA on both sides of the treatment group were higher than those before treatment(P<0.05 or P<0.01).The PI of both VA and BA decreased compared with before treatment(P<0.05).The control group RVA The Vs of Vm and BA were higher than those before treatment(P<0.05),and the other indexes were not statistically significant.Compared with the control group,the Vs and Vm of VA and BA on both sides of the treatment group were higher than those of the control group(P<0.05 or P<0.01),and the PI of both sides of VA and BA were lower than the control group(P<0.05).It is suggested that both groups of drugs can increase the velocity of vertebral artery and basilar artery blood flow and decrease the PI value,while the treatment group is more effective than the control group.6.Comparison of blood rheology between the two groups: The low blood viscosity and plasma viscosity of the two groups were lower than those before treatment(P<0.05).Compared with the control group,the whole blood viscosity of the treatment group was lower than that of the control group(P<0.05).7.In terms of safety indicators,both the laboratory and ECg indicators before and after treatment were in the normal range,indicating that both groups of drugs were safe and the risk of adverse events was low.Conclusion:Tongqiao Dingxuan Decoction combined with betahistine has significant efficacy in treating ischemic vertigo(syndrome of phlegm and blood stasis obstructing orifices),and its effective rate is higher than that of western medicine alone.It can alleviate clinical symptoms and signs,and has advantages in improving blood flow parameters and plasma viscosity.The adverse drug reaction occurs,so the clinical promotion of this side is safe and effective.