| 【Objective】 To explore altered functional connectivity of default mode network in patients with conventional magnetic resonance negative temporal lobe epilepsy,the rest-state functional magnetic resonance inmaging with independent component analysis were used to analyze the default mode network in patients with conventional magnetic resonance negative temporal lobe epilepsy.So the pathogenesis and pathophysiological of conventional magnetic resonance negative temporal lobe epilepsy could be better understood.【Materials and Methods】We selected 16 patients with conventional MRI-negative left temporal lobe epilepsy and 26 patients with left medial temporal lobe epilepsy associated with hippocampal sclerosis,and 24 normal persons.All subjects underwent sagittal T1WI-3D and rest-state functional MRI using a Siemens 3.0T Trio Tim magnetic resonance scanner.All subjects were collected for general data and cognition function assessment before magnetic resonance scan.The general data included: age,gender,education,and duration of epilepsy.We used Montreal Cognitive Assessment test cognitive level of all subjects.The magnetic resonance imaging data were pretreated with MATLAB 2010 platform.SPM12 software and GICA kits were used to analyze the DMN brain regions,while functional connectivity values of different brain regions in the DMN were extracted.SPSS software was used to compare the three groups of the clinical data of the patients,the cognition function assessment and functional connectivity values of different brain regions.【Results】 1.General clinical data and cognitive function evaluation results: There were no significant variations in age,sex,education years and course of disease among the three groups,and Mo CA scale scores did not differ much among the three groups.In comparison with the normal control group,the Mo CA score in the conventional MRI-negative temporal lobe epilepsy group and the medial temporal lobe epilepsy with hippocampal sclerosis group was extensively decreased.There was no significant difference between the conventional MRI-negative temporal lobe epilepsy group and the medial temporal lobe epilepsy with hippocampal sclerosis group in Mo CA score.2.In comparison with the normal control group,the functional connectivity of bilateral praecuneus/posterior cingutate in the conventional MRI-negative temporal lobe epilepsy group and the medial temporal lobe epilepsy with hippocampal sclerosis was extensively decreased.However,In comparison with the medial temporal lobe epilepsy with hippocampal sclerosis group,the number of voxel with decreased functional connectivity in bilateral praecuneus/posterior cingulate cortex the conventional MRI-negative temporal lobe epilepsy group was reduced.3.In comparison with the medial temporal lobe epilepsy with hippocampal sclerosis group,the functional connectivity of left medial prefrontal cortex/anterior cingulate cortex in the conventional MRI-negative temporal lobe epilepsy group and the medial temporal lobe epilepsy with hippocampal sclerosis was extensively decreased.【Conclusion】 1.The conventional MRI-negative temporal lobe epilepsy and the medial temporal lobe epilepsy with hippocampal sclerosis have cognitive impairment.2.The bilateral praecuneus/posterior cingutate has lower degree of injury in the left conventional MRI-negative temporal lobe epilepsy group than the left medial temporal lobe epilepsy with hippocampal sclerosis group’s.3.The conventional MRI-negative temporal lobe epilepsy and the medial temporal lobe epilepsy with hippocampal sclerosis have different brain networks,and patients with the conventional MRI-negative temporal lobe epilepsy have a wider range of abnormal brain areas in the default mode network.MRI-negative temporal lobe epilepsy is an independent subgroup of temporal lobe epilepsy. |
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