| ObjectiveBased on the theory of " Psycho-Cardiology treatment",this study explored the intervention effect and mechanism of XinLing Wan on patients with acute coronary syndrome(ACS)complicated with anxiety and depression.MethodsThis study is divided into clinical research and basic research.1.Clinical study:60 ACS patients with anxiety and depression were randomly divided into treatment group and control group,30 cases each group.The control group was given routine treatment XinLing Wan of ACS,and the treatment group was given additional intervention of on the basis of routine treatment,with a course of treatment of 1 month.The TCM syndrome score,Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)and Seattle angina pectoris scale(SAQ),adverse reaction events and other data of the patients before and after treatment were compared and analyzed.2.Basic research:40 male Wistar rats with body mass(180±20)g were randomly divided into blank group,model group,XinLing Wan group,and Sertralin group,each group had 10 rats.Chronic unpredictable stress for 21 days was used to construct the depression rat model.To observe the effect of XinLing Wan on behavior and serum 5-HT content in depressed rats,the behavioral indexes of rats included body mass,open box test,sugar water consumption test,etc,and the 5-HT content was determined by enzyme linked immunoassay(ELISA).Resu ts1.Clinical study(1)Curative effect of TCM syndromes:the total effective rate of the treatment group was 60.0%,while that of the control group was 26.7%.The difference between the two groups was statistically significant(P<0.05).(2)Seattle angina scale score:the degree of physical limitation,stable state of angina,angina attack,treatment satisfaction and disease cognition of the two groups were improved after treatment(P<0.05),and the improvement of treatment satisfaction of the treatment group was better than that of the control group(P<0.05).(3)Hamilton anxiety scale(HAMA)score:the total effective rate of the treatment group was 63.33%,and that of the control group was 43.33%,but the difference between the two groups was not statistically significant(P<0.05).(4)Hamilton depression scale(HAMD)score:the total effective rate of the treatment group was 66.67%,while that of the control group was 40.00%.The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).(5)Adverse reactions:There were no adverse reactions occurred during the treatment in the two groups.2.Basic research(1)Behavioral indexes of depressed rats①Body mass:the model group was lower than the blank group,and the difference was statistically significant(P<0.05).Both Chinese patent medicine group and western medicine group were higher than the model group,but the difference was not statistically significant(P>0.05).②Open box test:the activity time,total distance,average speed,activity frequency and activity degree of open box test in rats in the model group were all lower than those in the blank group,and the difference was statistically significant(P<0.05).The activity time and activity of open box test in western medicine group were higher than that in model group,and the difference was statistically significant(P<0.05).The activity time and activity of the open-box test in rats of the Chinese patent medicine group were higher than that of the model group,and the difference was statistically significant(P<0.05).The activity time,total distance,average speed,activity frequency and activity degree of the open-box test in rats of the Chinese patent medicine group were the same as those of the western medicine group(P=1.000),and the difference was not statistically significant(P>0.05).③Sugar water consumption test:in terms of sugar water preference rate,the model group was significantly lower than the blank group,and the difference was statistically significant(P<O.05).Chinese patent medicine group and western medicine group were higher than model group,and the difference was statistically significant(P<0.05).Chinese patent medicine group was higher than western medicine group,and the difference was statistically significant(P<0.05).(2)Serum 5-HT content in rats:the model group was lower than the blank group,Chinese patent medicine group and western medicine group,and the difference was statistically significant(P<0.05).Both the Chinese patent medicine group and the western medicine group were higher than the model group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups(P>0.05).Conclusion1.Clinical study(1)XinLing Wan has certain clinical efficacy in treating ACS patients with anxiety and depression;(2)XinLing Wan has a significant effect on the improvement of TCM symptoms in ACS patients with anxiety and depression;(3)XinLing Wan can improve the depression of ACS patients with anxiety and depression;(4)XinLing Wan can improve the satisfaction degree of ACS patients with anxiety and depression for treatment;(5)In the treatment of ACS patients with anxiety and depression,the patients are safe.2.Basic research:(1)XinLing Wan can improve the depression state of depressed rats with chronic unpredictable stress;(2)the mechanism of action of XinLing Wan on ACS patients with anxiety and depression may be related to the inhibition of 5-ht reuptake in blood. |
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