Analysis Of The Correlation Between Infant Kawasaki Disease And Infant Feeding Behavior

Objective:To explore the importance of breastfeeding in infant KD and provide clinical basis for early prevention and treatment of KD,we analyzed the correlation between different feeding methods and clinical manifestations,laboratory detection indicators and coronary artery injury in infant Kawasaki disease(KD).Methods:Firstly,the clinical data of 581 KD children hospitalized in Children’s Hospital Affiliated to Suzhou University from August 2016 to November 2018(symptoms,signs,laboratory examination results and color Doppler echocardiography results)were collected[see Schedule 1 for details];secondly a questionnaire on infant feeding was developed,and the father of the selected KD children was selected.Mothers were interviewed by telephone and questionnaires were conducted.Questionnaire survey included age(month age),sex,family living environment,relationship between telephone respondents and children,mother’s education level,birth weight,infant feeding behavior(including breastfeeding after birth,breast milk start and cut-off time,when to add milk powder,when to add supplementary food)[Detailed see Table 2].The infants were divided into breast-feeding group(226 cases),mixed feeding group(278 cases),artificial feeding group(77 cases),and the three groups were statistically analyzed between clinical manifestations,laboratory results and coronary artery injury.Results:(1)Among the 581 children surveyed,192 were coronary artery lesions,accounting for 33.05%of the total.Among them,67 cases of coronary artery injury in breast-fed group,the proportion was 29.65%;85cases of coronary artery injury in mixed feeding group,the composition ratio was 30.58%;40 cases of coronary artery injury in artificial feeding group,the composition ratio was 51.95%.The rate of coronary artery injury in the breast-fed group was lower than that in the artificial feeding group.The rate of coronary artery injury in the mixed-feeding group was lower than that in the artificial feeding group.There was a statistically significant difference between the two groups,P<0.017.(2)In the breast-fed group and the artificial feeding group,the time of supplementation,laboratory tests including acute white blood cell count,acute phase hemoglobin count,acute erythrocyte sedimentation rate(IVIG),and alanine aminotransferase(acute/subacute phase)There is a statistical difference,that is,P<0.05 or P<0.017;(3)There were statistical differences in the education level,living standard and birth parity of the 581 children with KD in the breast-fed,mixed-feeding and artificial-fed groups,ie P<0.05 orP<0.017;(telephone receiver,gender,birth weight),clinical manifestations(including fever days,cervical lymphadenopathy,lip changes,hand and foot changes,rash,conjunctival hyperemia),laboratory test results(including acute platelet count,neutral)There was no significant difference in percentage of granulocytes,C-reactive protein,albumin,leukocytosis,urinary albumin,serum sodium ion,serum potassium ion,creatine kinase isoenzyme,ie P>0.05.Conclusion:1.Breastfeeding can reduce the incidence of coronary artery injury in infants with KD,and breastfeeding should be actively promoted.2.Breastfeeding may reduce the incidence of anemia in infants with KD.3.Breastfeeding may reduce the incidence of liver damage in infants with KD.4.Breastfeeding may reduce the degree of inflammation in infants with KD.