A Survey On Sleep Quality And Its Influencing Factors In Maintenance Hemodialysis Patients

Objective: By exploring the sleep quality and melatonin levels of patients with maintenance hemodialysis,and analyzing the possible influent factors,this study contributes to provide new statistic data of treating insomnia for these patients.Methods:Choose between December 2017 and May 2018 in Xin jiang medical university affiliated hospital kidney disease blood purification center 5 regular hemodialysis,160 patients with more than 3 month,for the Pittsburgh sleep quality index scale(PSQI)score,according to the results of the MHD patients score divided into sleep disorder group(127 cases)and the sleep disorder group(33 cases),while in the 60 cases of normal healthy people sleep as healthy controls.All clinical data were collected through questionnaire survey,and all subjects’ serum Melatonin(MT),IL-6,CRP,intact parathyroid hormone(iPTH),blood routine and biochemical indicators were detected in the morning.MT level of hemodialysis patients was retested after dialysis.MT level was detected by ELISA.Taking melatonin as the dependent variable,multiple linear regression analysis was conducted to analyze the influence factors of melatonin level and PSQI score in patients with maintenance hemodialysis.Results : The incidence of sleep disorders in dialysis patients was 79.4%.The factors affecting melatonin level in dialysis patients include various hemodialysis,increased CRP,increased IL-6,high iPTH and decreased hemoglobin(P<0.05),while different dialysis modes had no significant influence on MT level(P>0.05).The main influencing factors of sleep quality in dialysis patients were age,dialysis age,iPTH,Kt/V,hemoglobin,creatinine level and melatonin level(P<0.05).Conclusion: The incidence of sleep disorders is high in patients with maintenance hemodialysis.Serum MT level was seriously decreased,anemia,high iPTH,dialysis age,creatinine level,IL-6,CRP and other factors affected the sleep quality of dialysis patients.IL-6,CRP,hemodialysis,anemia,iPTH,creatinine and other factors also affect serum MT level.How to improve patients’ inflammatory level,anemia,high PTH and creatinine level can directly improve sleep state,and possibly improve sleep state by improving serum MT level.There was no significant difference in the clearance effect of serum MT between different dialysis modes.