The Study Of Low-temprature Plasma Ablation Of Dorsal Root Ganglion Combined With Medical Administration On The Treatment Of Postherpetic Neuralgia

Objective:To study the efficacy and safety of low-temperature plasma ablation of dorsal root ganglion(DRG)combined with medical administration on the treatment of postherpetic neuralgia(PHN).Methods: Sixty patients with thoracic segment(T3-T12)PHN admitted to the pain department of the first affiliated hospital of bengbu medical college from January 2017 to December 2017 were selected for this study and randomly divided into three groups.Group?received medical administration,group?received medical administration combined with paravertebral nerve block,and group?received medical administration combined with low-temperature plasma ablation of dorsal root ganglion.20 cases in each group.Short-form of Mc Gill pain questionnaire was assessed before treatment and at 1 week,2weeks,4weeks,8weeks,12 weeks and 24 weeks after treatment.Patients' Sleep quality was assessed by Pittsburgh Sleep quality Index(PSQI)before treatment and 4weeks and 8 weeks after treatment.Record the occurrence of complications.Results: 1.There were no significant differences in gender,age and course of disease among the three groups(P>0.05).2.The three groups had no significant differences in the pain rating index(PRI),visual analogous scale(VAS)and present pain intensity(PPI)before treatment(P >0.05).The scores of SF-MPQ were significantly decreased after treatment among all three groups.At 1,2,4,8,12,24 weeks after treatment,the PRI,VAS and PPI scores of the ?groups were significantly lower than those of the?group,the difference was statistically significant(P< 0.05).At 1,2,4,8,12 weeks after treatment,the PRI,VAS and PPI scores of the ?groups were significantly lower than those of the?group,the difference was statistically significant(P<0.05).At 24 weeks after treatment,There were no significant differences in scores of PPI,VAS between group ?and group ?(P>0.05).At 2 weeks,4 weeks,8 weeks,12 weeks and 24 weeks after treatment,the scores of PPI,VAS of group ?significantly lower than 1 weeks after treatment(P< 0.05).3.Before treatment,there were no significant differences in scores of PSQI among the three groups(P>0.05).At 4 weeks and 12 weeks,the scores PSQI of three groups were significantly decreased,the difference was statistically significant(P < 0.05).At 4weeks and 12 weeks after treatment,the scores of PSQI in group ?and ? were significantly lower than those of group ?(P<0.05),but there were no significant differences between group ?and group ?(P>0.05).4.There were no obvious complications in group ?and group ?,there were no statistically significant differences in incidence of adverse reactions among three groups.Conclusion: 1.In terms of pain control and sleep improvement in patients with PHN,all three treatments showed evident efficacy.2.low-temprature plasma ablation of dorsal root ganglion combined with medical administration can provide more lasting pain reduction and without obvious complications,so it is safe on the treatment of postherpetic neuralgia.