Posterior Circulation Cerebral Blood Perfusion Of Vertebrobasilar Dolichoectasia In Elderly Patients

Part I Posterior Circulation Cerebral Blood Flow of Vertebrobasilar Dolichoectasia in Elderly patientsPurpose:This study quantitatively measured gender differences in cerebral blood flow(CBF)values using arterial spin labeling(ASL)magnetic resonance imaging(MRI)in people over 80 years of age.Materials and Methods:The study was performed in 103 healthy volunteers(58 men,45 women)with no history of central nervous system disease,and MRI was used to measure their CBF in the resting state.The CBF values were measured by 3 dimensions pseudocontinuous arterial spin labeling(3DpCASL)MRI with postlabeling delay(PLD)times of 1525ms and 2525ms.The CBF values in the gray matter of men and women were compared in each brain lobe.Results:Elderly women had higher CBF values than men of the same age in whole brain gray matter(p<0.0001).This effect was also observed for various regional mean gray matter values including the frontal cortex,parietal cortex,occipital cortex,temporal cortex,insula thalamus,basal ganglia and cerebellum(p<0.0001).Conclusion:For two different PLD times,the CBF values in men over 80 years old were much lower than those of women of the same age.These findings demonstrate the difference between regional CBF and gender,enhancing our understanding of pathological mechanisms in older people.Gender-related differences in CBF may be related to the incidence of nervous system vascular diseases.Part ? Posterior Circulation Cerebral Blood Flow of Vertebrobasilar Dolichoectasia in Elderly patientsPurpose:To investigate the effects of vertebrobasilar dolichoectasia(VBD)on cerebral blood flow in the posterior circulation supplied areas,and to analyze the relationship between morphological changes of the basilar artery and delayed perfusion in the elderly.Methods:A retrospective study of patients admitted to the Second Medical Center of the Chinese PLA General Hospital from February 2016 to February 2018,24 patients with VBD diagnosed by magnetic resonance angiography(MRA),and 25 normal elderly controls.The magnetic resonance scan data of 3D-pCASL(PLD=1525ms,PLD=2525ms)were measured,and the cerebral blood flow(CBF)values of the parietal lobe,occipital lobe,thalamus and cerebellum cortex were measured by SPM12 software,the post-circulation delayed cerebral blood flow was calculated.The independent sample t test was used to compare the delayed cerebral blood flow differences between the VBD group and the control group.RESULTS:In the VBD group at 1525 ms,the CBF values in the posterior circulation were lower in the control group.The CBF difference between the parietal occipital lobe,occipital lobe,thalamus and cerebellum was statistically significant(p=0.015,p=0.003,p=0.044,p=0.033);while the PLD time was 2525ms,there was no significant difference in the CBF value between the VBD group and the control group;the delayed cerebral blood flow ratio in the VBD group was higher than that in the control group,bilateral parietal lobe,occipital lobe,The CBF difference between the thalamus and the cerebellum was statistically significant(p=0.003,p=0.003,p=0.008,p=0.004).Conclusion:The patients with vertebrobasilar dolichoectasia have a slower post-circulation blood flow velocity,and delayed perfusion is significant,but does not affect the maximum perfusion value of cerebral blood flow.There was no difference in post-circulation cerebral blood flow between the VBD patients and the control group.