Correlation Analysis Between GM-CSF Antibody And Inflammatory Bowel Disease

Objecteve:To investigate the differential expression of GM-CSF antibodies in serum of patients with ulcerative colitis(UC)and Crohn's disease(CD)by detecting the expression level of GM-CSF antibodies in serum of patients with inflammatory bowel disease(IBD),and the significance of GM-CSF antibodies in assessing disease activity in patients with Crohn's disease(CD).Methods:Serum GM-CSF antibodies levels in 52 patients with IBD(CD37,UC15)and 21 healthy controls were detected by enzyme-linked improliferation munosorbent assay(ELISA).Results:The serum concentrations of GM-CSF antibodies were respectively(1.22±0.54)ug/ml,(0.41±0.51)ug/ml and(0.47±0.34)ug/ml in CD patients,UC patients and healthy controls.The serum GM-CSF antibodies level from CD patients was higher than that from the healthy controls and UC patients,the difference was statistically significant(P<0.05).In addition,the serum GM-CSF concentrations from CD patients were elevated with disease activity increasing,the difference was statistically significant between ranks(P<0.05).Conclusion:The expression of serum GM-CSF antibodies has a differential significance for patients with UC and CD.For CD patients,it has the significance of assisting diagnosis,and has a certain significance for evaluating the disease activity of CD patients.