Correlation Analysis Of The Effects Of Sociological Factors And Dichloroacetic Acid, Trichloroacetic Acid Exposure On Telomere Length: A Cross-sectional Study In China

Objective: Telomeres play an important role in maintaining the integrity and stability of chromosome structure,which is closely related to human health.Sociological factors may impact telomere length.A few studies have analyzed the association between sociological factors and telomere length.But existing researches are inconsistent.Therefore,the objesct is to analyze the associations between sociological factors and telomere length.Moreover,dichloroacetic acid(DCAA)and trichloroacetic acid(TCAA)have been widely detected in human samples,suggesting the change of telomere length.However,the associations between DCAA and TCAA exposure and the change of telomere length have not been studied to date.Therefore,we also examine the associations between DCAA and TCAA exposure and the change of telomere length.Our results may povide the sociological and etiological evidences for the future researches about the change of telomere length.Methods:We recruited 540 subjects who presented themselves to the primary health care center of the Third Hospital of Hebei Medical University.They were all adults aged from 18 to 45 years old.All participants were required to complete a questionnaire containing demographic factors(age,gender,marital status,et al.),individual behaviors(smoking,alcohol drinking,et al.)and health status.Collected urine sample was used to examine the urinary DCAA and TCAA concentrations by internal standard method.Results:The range of telomere relative length was from 5.73 to 7.77,the median concentrations of telomere relative was 6.44.Among the sociological features,only gender was correlated with the length of telomere.Compared with the subjects of males,the length of telomere in subjects of femalewere higher.The mean concentrations of urinary DCAA and TCAA were 4.76 ?g/L and 4.82 ?g/L,respectively.The concentrations of urinary TCAA levels exhibited a significant positive dose-related relationship with the length of telomere.Compared to the reference group(the first quantile),the length of telomere increases in the tenth quantile.The concentrations of DCAA exhibited no relationships with the length of telomere.Conclusions:Gender is the effect factors of the length of telomere.Compared with the length of telomere in the subjects of male,the length of telomere in the subjects of female was longer.Urinary TCAA levels are positively associated with the length of telomere,suggesting that exposure to TCAA may be a risk factor for the increase of the length of telomere.Therefore,we should further explore other factors associated with gender to control the TCAA exposure.Regulation relevant interventions should draw more attention in further researches.