The Clinical Study On The Treatment Of Female Chloasma Based On "Yangming Meridian Decline" Theory

Purpose:Under the guide of―randomized controlled trials clinical methods,‖the study is to observe the clinical efficacy by using the method of "tonifying Yangming" to treat the chloasma in women over 35 years old,and to provided a new clinical idea for the treatment of chloasma with acupuncture and moxibustion.Method:Those who met the criterions were randomly divided into two groups,and both groups contained 30 cases.The subjects in study group were treated by acupuncture combined with traditional Chinese medicine,the subjects in control group were treated with drugs recommended by the guidelines,including oraling Vc and Ve,wiping tretinoin.These groups were treated 4 weeks as a course,and 2 courses of a total treatment.The scores of skin lesions area,color,total score of skin lesions,anxiety was recorded before treatment,a half of the treatment,two courses of treatment,and follow-up,analyzing those data,and drawing the conclusion of the clinical efficacy and safety of the two groups.Result:1.Before treatment,the baseline of the two groups in ages,courses of the disease,total scores of skin lesions,total scores of anxiety are comparable.2.Total score of skin lesions: Statistical analysis showed that P<0.05 in the study group own control before treatment and mid-treatment,middle stage and after treatment,before treatment and follow-up after 2 months in total score of skin lesions,but P>0.05 own control after treatment and follow-up after 2 months.Statistical analysis showed that P < 0.05 in the control group own control before treatment and mid-treatment,before treatment and follow-up after 2 months in total score of skin lesions,but P>0.05 own control middle stage and after treatment,after treatment and follow-up after 2 months.It is showed P>0.05 in total scores between the two groups at each evaluation except follow-up stage.Lesion area scores: Statistical analysis showed that P<0.05 both of the two groups own control before treatment and mid-treatment,before and follow-up after 2 months,but P>0.05 own control middle stage and after treatment,after treatment and follow-up after 2 months.It is showed P>0.05 in lesion area scores between the two groups at each evaluation except follow-up stage.Lesion color depth scores: Statistical analysis showed that P<0.05 in the study group own control before treatment and mid-treatment,middle stage and after treatment,before treatment and follow-up after 2 months in color depth scores,but P>0.05 own control after treatment and follow-up after 2 months.Statistical analysis showed that P<0.05 in the control group own control before treatment and mid-treatment,before treatment and follow-up after 2 months in color depth scores,but P>0.05 own control middle stage and after treatment,after treatment and follow-up after 2 months.It is showed P<0.05 in lesion color depth scores between the two groups at each evaluation except after stage.Lesion color uniformity scores: Statistical analysis showed that P<0.05 in the study group own control mid-treatment and after treatment,before treatment and follow-up after 2 months in color depth scores,but P>0.05 own control before treatment and mid-treatment,after treatment and follow-up after 2 months.Statistical analysis showed that P<0.05 in the control group own control before treatment and mid-treatment,after treatment and follow-up after 2 months in color uniformity scores,but P>0.05 own control middle stage and after treatment,before treatment and follow-up after 2 months.It is showed P>0.05 in color uniformity scores between the two groups at each evaluation except follow-up stage.3.HAMA scores: Statistical analysis showed that P<0.05 both of the two groups own control before and after treatment,but P>0.05 in the control group own control before treatment and after treatment.Statistical analysis showed that P< 0.05 between the two groups before and after treatment in anxiety scores,at the same time,P< 0.01 in mental anxiety scores between the two groups,and P>0.05 in physical anxiety between groups.4.The overall effect: the effective rate of study group was 70%,and 66.67% in the control group in mid-treatment;after treatment,the effective rate of study group was 83.33% and 70% in the control group;at follow-up after 2 months,the effective rate of study group was 80%%,and 53.33% in the control group.There was no statistical difference between them at at each evaluation except follow-up stage.Conclusion:1.The treatment based on the "Yangming meridian decline" theory is clinically effective to treat female patients with chloasma over 35 years old.2.The treatment based on the "Yangming meridian decline" theory can improve the anxiety of patients,especially the mental anxiety.3.Comparing the treatment based on the "Yangming meridian decline" theory with the regimen recommended by the guidelines,the overall efficacy of the two regimens is equal,but the study group have more advantages in improving patients’ anxiety,controlling recurrence and safety.