| Purpose: Through the observation and analysis of clinical cases,the effects of external application of tongtong powder on severe pancreatic cancer pain and its impact on patients’ quality of life were summarized,and the clinical treatment value of traditional Chinese medicine acupoint application on pancreatic cancer pain was comprehensively analyzed.Methods: A total of 62 patients with severe pancreatic cancer pain who met the inclusion criteria in the outpatient department of oncology and inpatient department of the affiliated hospital of chengdu university of traditional Chinese medicine from December 2016 to December 2018 were collected and counted.Patients were divided into control group(n=31)and treatment group(n=31)according to the random number table method.The patients in the control group were given standardized treatment for cancer pain,and the patients in the treatment group were treated on the basis of the combination of traditional Chinese medicine tongtong powder acupoint application.Observe two groups after treatment in patients with pain relief situation and adverse reactions occur,compared two groups of patients before and after treatment the degree of pain relief,quality of life score,negative emotional score,adverse reaction rate and other related data,the data obtained using the statistical software for statistical analysis,statistical results,and then to the safety of traditional Chinese medicine acupuncture point were applied in treatment of pancreatic cancer pain and curative effect evaluation.Results:Observation and analysis of clinical effect of application of pain powder acupoint combined with opioids in the treatment of severe pancreatic cancer pain showed no statistical difference in gender,age,tumor stage,pain NRS score,KPS score and incidence of pain outbreak between the treatment group and the control group before admission(P > 0.05).In terms of pain efficacy,the total effective rate of pain treatment in the control group was 93.5%,and the significant efficiency was54.8%.The total effective rate of pain treatment in the treatment group was 96.7%,and the significant efficiency was 67.7%.According to the likelihood ratio chi-square test,there was no statistically significant difference in the total effective rate and significant efficiency between the two groups(p > 0.05).There was no statisticallysignificant difference in the frequency of pain outbreaks during treatment(P > 0.05).There was a statistically significant difference between the treatment group and the control group in the total dose of quick-acting painkiller for the treatment of outbreak pain(p < 0.05),and the total dose of morphine hydrochloride tablets for the treatment of outbreak pain in the treatment group was less than that in the control group.There was no statistically significant difference in KPS scores between the two groups before treatment(p > 0.05).After treatment,KPS scores of the two groups were improved compared with those before treatment,while the KPS scores of the control group were improved more significantly after treatment(p < 0.05).In terms of quality of life score,sleep score,appetite score,daily life score and attitude score of the control group and the treatment group were improved after treatment compared with before treatment,and the score of the treatment group was lower than that of the control group,with statistical difference(P<0.05).There was no statistically significant difference in negative emotional scores between the two groups before and after treatment(P<0.05).SDS scores and SAS scores of the two groups were lower than those before treatment,and the reduction was more significant in the treatment group(P<0.05).During the treatment period,no abnormal changes in general vital signs,blood cell analysis,liver function and renal function caused by the drug used in this study were found in all patients.During the treatment,the incidence of adverse reactions such as nausea,dizziness,dysuria and constipation in the treatment group was lower than that in the control group,which was statistically significant(P<0.05).Skin irritation was almost absent in the two groups,and the difference was not statistically significant(P>0.05).Conclusion:The combination of acupoint application of tongtong powder and oxycodone hydrochloride sustained release tablets in standardized pain treatment can reduce the pain degree of patients with severe pancreatic cancer pain,reduce the dose of opioids,improve their negative emotions and quality of life,and have fewer adverse reactions,which is worthy of clinical promotion. |
PDF Full Text Request