Development Of A Test Modular System For Pulsating Flow Performance Of Artificial Heart Valves

Heart valve disease is currently one of the major heart diseases with various causes such as rheumatism,degenerative and congenital,and the only treatment for patients with valvular disease is artificial heart valve replacement.The quality of the valve is directly related to the safety of the patient,so it is necessary to test and evaluate the performance indicators of the valve.Artificial heart valve in vitro testing is an important process before assessing the design and a prerequisite for entering the clinical trial.A modular artificial heart valve pulsation flow performance test system was designed.The system uses a motor to reciprocate to simulate the left ventricle,and the specific structure of the flow channel,valve,damping and compliance adjustment mechanism can simulate the hemodynamic characteristics in the circulatory system,and produce the liquid pressure waveforms and flow parameters needed for the pulsation flow performance test of the artificial heart valve,providing a convenient path for performance testing of artificial heart valves.The main research work of the dissertation is as follows:1.Summarizing the basic physiology knowledge of the human heart circulatory system,which is the test environment of the artificial heart valve,and the relevant parts and tissues of the human blood circulation system are introduced in detail.Based on physiological knowledge,simulating human blood circulation system,and analyzing the artificial heart valve test system in math and circuit to obtain the aortic blood pressure curve,left ventricular blood pressure curve,aortic blood flow curve and so on with the real human state.2.A novel modeling and simulation method for human blood circulation system is proposed.The heart and blood vessel network is analogized to a hydraulic system that consists of a hydraulic pump and a switch valve.The establishment of a hydraulic human blood circulation simulation system using open-loop control methods shows that this new modeling method is feasible.The hydraulic simulation method is relatively novel and few scholars are involved.3.The use of intelligent control algorithms is proposed to achieve closed-loop control,making the artificial heart valve pulsation flow test system more consistent with the physiological state of the human blood circulation system.4.Building artificial heart valve pulsation flow test platform.Completing mechanical design and software control system.The experimental results show that the test system successfully displays the simulation of the pulsating flow of the human circulatory system,and displays the changes in blood pressure and blood flow of the left ventricle and aorta in real time,which is suitable for evaluation of artificial heart valves,providing a good test environment for artificial heart valves.