Endoscopic Injection Of Carbon Nanoparticles For Lymph Node Detection After Laparoscopic Radical Resection Of Colorectal Cancer

Objective: The objective of this study is to investigate the value of preoperative endoscopic injection of carbon nanoparticles(CN)in detecting lymph nodes after laparoscopic radical resection of colorectal cancer(CRC).Methods: From March 2013 to January 2016,931 patients with colorectal cancer admitted to the gastrointestinal surgery department of the First Affiliated Hospital of Chongqing Medical University were enrolled in the experimental group(n = 358)and the control group(n = 573).Patients in the experimental group were treated with laparoscopic radical resection of colorectal cancer after endoscopic injection of carbon nanoparticles 1 to2 days before operation,while the atients in the control group were not injected,and the remaining operation was the same as that in the experimental group.The general data,lymph node dissection and postoperative complications between the two groups were analyzed and compared.Results: The experimental group had no adverse reactions,such as abdominal pain,diarrhea,fever,perforation,obstruction after injection of carbon nanoparticles.The average number of lymph nodes detected in the experimental group was higher than that in the control group(15.31 ±7.21 vs 11.05±5.53,P < 0.001).In the experimental group,the number of lymph nodes detected more than 12 of the proportion of patients was 63.4%,higher than the control group(40.1% in control group,P < 0.001);However,the lymph node metastasis rate was 7.3% in the experimental group,which was lower than 10.6% in the control group(P < 0.001),and the average number of metastatic lymph nodes in the experimental group was also lower than that in the control group(1.12 + 2.64)VS(1.48 + 2.63)(P <0.05).In addition,the metastasis rate of the experimental group was lower than that of the control group(P < 0.05).There was no significant difference in postoperative complications between the two groups(P >0.05).Conclusion: Preoperative endoscopic injection of carbon nanoparticles can effectively realize lymph node tracing and improve the detection number of lymph nodes.However,it may not have obvious advantages in increasing the number and detection rate of metastatic lymph nodes.