Levels Of S100b Proteins Correlate With Hypoxic-ischemic Encephalopathy In Neonates:A Meta Analysis

Objective: To systematically evaluate the relationship between serum,urine and umbilical cord blood S100 B protein levels and neonatal hypoxic ischemic encephalopathy(HIE).Methods: Taking "S100 protein,neonates,hypoxic ischemic encephalopathy" as the search term,we jointly searched Chinese HowNet journals,Weipu and Wanfang databases,using "S100 Proteins,Infant,Newborn,Hypoxia-Ischemia,Brain" as the search term,and jointly searched Pubmed,Embase and Ovid databases.From January 2019,we obtained the relevant articles for detecting the correlation between S100 B protein level and HIE.The relevant literature was screened and evaluated,and the data were extracted after inclusion.The Cochrane Library Rev Man 5.3 software was used for meta-analysis of the literature.Results: A total of 283 literatures were retrieved and 27 were included.The case-control study of serum HIE group and control group included 708 neonates with HIE and 494 healthy controls.Meta-analysis showed that the serum S100 B protein level of HIE neonates was higher than that of control group.The case-control study of serum HIE with light,medium and recombinant levels included 767 neonates with HIE and 273 healthy controls.Meta-analysis showed that the serum S100 B water of neonates with mild,moderate and severe HIE was higher than that of control group.The level of S100 B in urine of neonates with mild,moderate and severe HIE was higher than that of control group,and increased with the severity of HIE.The case-control study of HIE group and control group included 144 neonates with mild,moderate and severe HIE and 125 healthy controls.Meta analysis showed that the level of S100 B in urine of neonates with mild,moderate and severe HIE was higher than that of control group,and its level increased with the severity of HIE.Meta analysis showed that the serum S100 B protein level of 267 HIE neonates and 169 healthy controls was higher than that of the control group,and the above results had statistical significance.Conclusion: Serum S100 B protein level is an important index for the diagnosis of HIE,which is positively correlated with the severity of the disease.The level of S100 B protein in urine and umbilical cord blood has certain reference value for early diagnosis of HIE,and the level of S100 B protein in urine is positively correlated with the severity of the disease.