Study On Clinical Efficacy Of “Dispelling Pathogenic Wind And Dispersing Lung Qi” Method In Post Infectious Cough(Pathogenic Wind Attacking The Lung)

Objective Through randomized and parallel controlled methods,this study observe the effect of the influence of cough score,total points of TCM syndromes,Leicester cough questionnaire score,visual analogue scale score,fractional exhaled nitric oxide.Evaluating the clinical efficacy and safety of “dispelling pathogenic wind and dispersing lung qi” method in treating post-infectious cough.Methods Objects as syndrome of “wind evil invade lung” in the patients with post-infectious cough that be from outpatient department of Chengdu university of TCM are totally 72 cases.We divide patients into two groups according the random method on the basic principle of 1:1,36 cases in each group.Patients in the Chinese medicine are treated with “dispelling pathogenic wind and dispersing lung qi” method as Jiawei-Zhisousan decoction,and patients in the control group are treated with compound dextromethorphan hydrobromide syrup and ketotifen fumarate tablets.All patients are treated and observed for 5 days.To observe the efficacy index(the influence of cough score,secondary symptoms score,accompanying symptoms score,total points of TCM syndromes score,Leicester cough questionnaire score,visual analogue scale score,fractional exhaled nitric oxide)and safety indicators(transaminase,creatinine,vital signs).Data of each of the patients must be filled in case report form(CRF)before and after treatment and analyzed by SPSS22.0software.Results1.The two groups have consistency baseline on severity of illness and demographic data,so they are consistent and comparable. 2.Comparing the clinical efficacy,the treatment group is better than the control ,group in the aspects of the influence of cough score,secondary symptoms score,total points of TCM syndromes score,Leicester cough questionnaire score,visual analogue scale score,fractional exhaled nitric oxide.The rate on controlling and outstanding of the treatment group is 62.9%,the total effective rate is 91.4%.The rate on controlling and outstanding of the control group is 38.2%,the total effective rate is 82.4%.the difference is significant (P < 0.05). 3.The difference of clinical efficacy on accompanying symptoms between treatment group and control group is insignificant(P > 0.05). 4.Two treatment regimens both are safe.In both groups,the difference in aspects of transaminase,creatinine,vital signs between before and after treatment is insignificant(P > 0.05).Conclusion Curative efficacy of “dispelling pathogenic wind and dispersing lung qi” method in treating post-infectious cough is definite.With this method,the quality of life can be improved,the influence of cough score,total points of TCM syndromes score,visual analogue scale score can be reduced.