Analysis The IVF/ICSI Outcome Of Polycystic Ovary Syndrome Patients With Insulin Resistance

Objective: To investigate the effect of insulin resistance(IR)on the clinical outcome of in vitro fertilization or intracytoplasmic single sperm injection and embryo transfer(IVF/ ICSI-ET)in infertile patients with polycystic ovary syndrome(PCOS).Methods:Retrospective analysis the clinical data of 118 cases of patients with PCOS who receivd the IVF/ICSI-ET from January 2015 to December 2017 in the Reproductive Medicine Center of the Second Affiliated Hospital Of Chongqing Medical University.Acording to the Homeostatic Model Assessment for Insulin Resistance(HOMA-IR),those patients were divided into insulin resistance group(HOMA IR≥2.5)and non insulin resistance group(HOMA IR<2.5).Patients’ age,infertility years,body mass index(BMI),sex hormones,blood lipid,blood sugar and insulin levels,controlled ovarian hyperstimulation,pregnancy outcome and complications were compared in the two groups.Results:The level of BMI,bL H,LH/FSH,T,blood glucose,blood insulin and the use of gonadotropin doses and days in the ovulationpromoting cycle in the insulin resistance group were significantly higher than those in the non-insulin resistance group;the level of HDL in the insulin resistance group were lower than those in the non-insulin resistance group(P<0.05).The clinical pregnancy rate and live birth rate in the insulin resistance group were lower than those in the non-insulin resistance group,and the incidence of gestational diabetes in the insulin resistance group was significantly higher than that in the non-insulin resistance group,with statistically significant differences(P < 0.05).The two groups showed no significant differences in age,infertility years,the level of E2,AMH,number of oocyte retrieved,fertilization rate and embryo quality rate,and incidence of ovarian hyperstimulation syndrome(OHSS)(P > 0.05).Conclusion:Insulin resistance has adverse effects on the pregnancy outcome of patients with PCOS,and PCOS patients with infertility should actively evaluate their insulin resistance.