Analysis Of The Correlation Between Mild Cognitive Impairment And Blood Pressure Variability In The Elderly

Objective: To investigate the correlation between mild cognitive impairment(MCI)and blood pressure variability(BPV)in the elderly.Methods: According to inclusion criteria and exclusion criteria,The elderly aged ≥ 60 years old were randomly enrolled in the first affiliated Hospital of Medical College of Shihezi University to be treated with 24-hour ambulatory blood pressure monitoring.Collect general patient data,laboratory examination results,24-hour ambulatory blood pressure monitoring index and variation index,Evaluation of patients’ Cognitive function by Montreal cognitive assessment(Mo CA)and Mini-mental state examination(MMSE),After matching sex,age and educational level,A total of 300 cases were included in the study,Among them,150 patients with mild cognitive impairment were MCI group,150 patients without cognitive dysfunction as control group,Analysis of the relationship between mild cognitive impairment and blood pressure variability by statistical software,P < 0.05 was statistically significant.Results:There was no significant difference in sex,age,education level,smoking history and drinking history between MCI group and control group in terms of sex,age,education level,smoking history and drinking history of BMI(P>0.05).In MCI group and control group,fasting blood glucose,total cholesterol,high density lipoprotein,triglyceride,low density lipoprotein,cystatin C,homocysteine,serum creatinine,serum urea nitrogen and glutamic pyruvic transaminase were measured.There was no significant difference among biochemical indexes such as glutamic-oxaloacetic transaminase(P>0.05).The total scores of MMSE and Mo CA,nocturnal systolic blood pressure(SBP),nocturnal diastolic blood pressure(DBP),large pulse pressure difference(PP)and non-dipper shape of blood pressure circadian rhythm were positively correlated with decreased cognitive level(P<0.05).In the MMSE cognitive functional areas,namely,orientation,memory,attention and calculation,recall,language ability sub-scoring study showed,Nocturnal systolic hypertension and pulse pressure difference were negatively correlated with memory,attention,calculation and recall.Nocturnal diastolic blood pressure and morning peak blood pressure were negatively correlated with recall ability.The non-dipper shape of blood pressure variation was negatively correlated with attention and computational power(P<0.05).Conclusion:The mild cognitive impairment in the elderly is closely related to the blood pressure variability;Nocturnal systolic hypertension and pulse pressure difference are mostly associated with memory,attention,calculation and memory impairment,nocturnal diastolic blood pressure and morning peak blood pressure are associated with memory impairment,the circadian rhythm of blood pressure is non-dipper related to attention and computational impairment.