Correlation Between Serum Uric Acid Level After Liver Transplantation And Gout Susceptibility Genotypes

Objective: to study the correlation between the gene mononucleotide polymorphism(SNP)sites of donor recipients of hyperuricemia(HUA)after liver transplantation(LT)and the uric acid metabolism and elevated blood uric acid levels in liver transplant recipients,and to provide a basis for further study on the mechanism of donor recipient genotype and the occurrence of hyperuricemia in transplant recipients.Methods: the genomic DNA of donor/recipient hepatocytes was extracted from 94 patients who received LT surgery in the affiliated hospital of Qingdao university from2015 to 2016.Juno 96.96 Genotyping IFC(Fluidigm,US)was used for Genotyping.Results: Logistic regression analysis showed that rs2107538 polymorphism of receptor CCL5 gene may be correlated with the incidence of hyperuricemia after transplantation.Compared with the C: C genotype,patients with C: T genotype have a lower probability of hyperuricemia.The rs1801131 polymorphism of donor MTHFR gene is correlated with the occurrence of hyperuricemia after liver transplantation.Compared with A: A genotype,patients with A: C genotype have A higher probability of hyperuricemia.No other donor/recipient SNP polymorphism has been found to be associated with the incidence of hyperuricemia after transplantation.Conclusion: The polymorphism of rs2107538 of receptor CCL5 gene and rs1801131 of donor MTHFR gene is related to the incidence of hyperuricemia after transplantation.The incidence of hyperuricemia is lower in patients with C: T genotype and higher in patients with A: C genotype.The other SNP polymorphisms were not correlated with the occurrence of hyperuricemia after liver transplantation.