| Objective:To investigate the relationship between Helicobacter pylori(Hp)infection and the expression of transforming growth factor beta receptor II(TGF-beta R II),tumor necrosis factor-?(TNF-?),interleukin-18(IL-18)and interleukin-33(IL-33)in gastric mucosa of patients with chronic atrophic gastritis.Methods:A retrospective analysis was made of 83 patients with chronic atrophic gastritis admitted to our hospital from March 2017 to March 2018.Analysis of patients with Hp infection.The expression of TGF-beta R II,TNF-?,IL-18 and IL-33 in gastric pit epithelium and interstitial inflammatory cells were analyzed by Fluorescence quantitative real-time PCR and immunohistochemical methods.Results:(1)83 patients,47 were positive for Hp,the positive rate was 56.63%(47/83).(2)There was no significant difference in the expression intensity of TGF-beta R II,TNF-a,IL-18 and IL-33 in gastric pit epithelium between the positive group and the negative group(P > 0.05);there was no significant difference in the expression intensity of TGF-beta R II and TNF-a between the two groups(P > 0.05);the positive and strong positive ratio of IL-18 and IL-33 in the positive group was higher than that in the negative group(P < 0.05).(3)There was no significant difference in atrophy degree,intestinal metaplasia severity and intraepithelial neoplasia between the two groups(P > 0.05);the proportion of severe chronic inflammation in positive group was higher than that in negative group(P < 0.05).(4)Spearman analysis showed that IL-18 and IL-33 were positively correlated with chronic inflammation(r = 0.37,0.52,P < 0.05),and atrophy was positively correlated with intestinal metaplasia and intraepithelial neoplasia(r = 0.65,0.31,P < 0.05).Conclusion:IL-18 and IL-33 in patients with chronic atrophic gastritis are related to the degree of chronic inflammation.The degree of chronic atrophy can affect intestinal metaplasia and intraepithelial neoplasia in patients with chronic atrophic gastritis. |
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