Study On The Factors Affecting Sexual Function Of Patients With Cervical Cancer After Concurrent Chemoradiotherapy

Objective: By evaluating the sexual function and quality of life of patients with cervical cancer after concurrent chemoradiotherapy in Inner Mongolia,the sexual function factors of patients after concurrent chemoradiotherapy were analyzed,which provided scientific basis for clinical work and clinical research in the future.Method: A total of 274 patients with cervical cancer in Inner Mongolia who were treated in our hospital from January 2015 to December 2017 were enrolled,including 106 premenopausal women and 168 postmenopausal women.According to the inclusion criteria of this study,65 premenopausal patients with cervical cancer(mean age 40 years)and postmenopausal 65 patients with cervical cancer(mean age 54.5 years)were selected as subjects.The Female Sexual Function Index(FSFI)before disease and the Female Sexual Function Index(FSFI)of the half a year after concurrent chemoradiotherapy were evaluated.The difference of sexual function were compared between before the illness and after treatment to premenopausal and postmenopausal cervical cancer patients.At the same time,the differences of sexual function between premenopausal and postmenopausal cervical cancer patients were compared in the half a year after treatment.The cancer patient quality of life scale(FACT-G)of the premenopausal and postmenopausal cervical cancer patients for half a year after treatment were evaluated.The differences were compared between quality of life of the premenopausal and postmenopausal women with cervical cancer after treatment for half a year and normal quality of life.The correlation between the each part’s score of FACT-G and the each dimension’s score of FSFI was analyzed to premenopausal and postmenopausal cervical cancer patients after half a year of treatment.In this study,all clinical materials were expressed as the composition ratio and mean ± standard deviation.The statistical methods were analyzed by t test,χ2 test and linear regression analysis.SPSS22.0statistical software was used for processing,the difference was considered statistically significant at P < 0.05.Results:(1)21.5%(14/65)patients with premenopausal cervical cancer had asexual life in half a year after concurrent chemoradiotherapy,72.3%(47/65)patients had decreased sexual life,and 6.2%(4/65)patients had no change in sexual function compared with before the disease.The each dimension’s score of FSFI of patients with premenopausal cervical cancer in the six months after concurrent chemoradiotherapy were significantly lower than those of the corresponding dimension of FSFI before the disease,and the difference was statistically significant(P<0.01).(2)32.3%(21/65)patients with postmenopausal cervical cancer had asexual life in half a year after concurrent chemoradiotherapy,64.6%(42/65)patients had decreased sexual life,and 3.1%(2/65)patients had no change in sexual function compared with before the disease.The scores of FSFI dimensions of postmenopausal cervical cancer patients in the six months after concurrent chemoradiotherapy were significantly lower than those before the disease,with statistically significant differences(P<0.01).(3)According to the FSFI scoring standard,the total score less than 26.55 is considered as sexual dysfunction;The rate of sexual dysfunction was 67.2%(41/61)in premenopausal patients with cervical cancer and 87.3%(55/63)in postmenopausal patients with cervical cancer.The rate of sexual dysfunction in patients with postmenopausal cervical cancer was significantly higher than that of premenopausal patients in the first half of the year after treatment,and the difference was statistically significant(χ2=7.154,P=0.010).The scores of sexual desire,sexual arousal,vaginal wetness,orgasm and sexual satisfaction of FSFI in the six months after concurrent chemoradiotherapy to premenopausal patients with cervical cancer were higher than those of the corresponding dimension of FSFI in the postmenopausal cervical cancer patients,and it were statistically significant differences(P<0.05).For the FSFI dimension of pain during intercourse,the score of pain during intercourse in the first half year after concurrent chemoradiotherapy to premenopausal cervical cancer patients was lower than that of postmenopausal cervical cancer patients in the half a year after treatment,and the difference was statistically significant(P<0.05).(4)The scores of FACT-G after the concurrent chemoradiotherapy were lower than those in the corresponding part of the FACT-G norm to the premenopausal and postmenopausal cervical cancer patients,and the differences were statistically significant(P<0.05).(5)The scores of physiological status,social/family status,emotional status and functional status of FACT-G after a half year with premenopausal and postmenopausal cervical cancer patients have positive correlated with the scores of the sexual desire,sexual arousal,vaginal moistness,orgasm,sexual satisfaction and dyspareunia of FSFI in the half year after treatment.The lower scores of FACT-G in the half year after treatment to cervical cancer patients leaded to the lower scores of the FSFI,and it was statistically significant(P<0.05).Conclusions: Sexual function of cervical cancer patients significantly decreased after chemoradiotherapy in Inner Mongolia.Cervical cancer patients have a negative effect on their physiological status,social/family status,emotional status and functional status after concurrent chemoradiotherapy in Inner Mongolia,and these negative effects are more likely to lead to lower sexual function after treatment.At the same time,with the increase of age,the overall sexual function of cervical cancer patients decreased significantly after concurrent chemoradiotherapy.